Exosomes: From Potential Culprits to New Therapeutic Promise in the Setting of Cardiac Fibrosis.

abstract：:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...

journal_title：Cells

authors： Liu J,Wang L,Wang Z,Liu JP

更新日期：2019-01-15 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in or near the IL2RA gene, that encodes the interleukin-2 (IL-2) receptor α (CD25), are associated with increased risk of immune-mediated diseases including multiple sclerosis (MS). We investigated how the MS-associated IL2RA SNPs rs2104286 and rs11256593 are associated with CD25...

journal_title：Cells

authors： Buhelt S,Søndergaard HB,Oturai A,Ullum H,von Essen MR,Sellebjerg F

更新日期：2019-06-25 00:00:00

abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In t...

journal_title：Cells

authors： Taguchi YH,Wang H

更新日期：2018-12-05 00:00:00

abstract：:Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dy...

journal_title：Cells

authors： Peta C,Tsirimonaki E,Samouil D,Georgiadou K,Mangoura D

更新日期：2020-10-23 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00

abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...

journal_title：Cells

authors： Harel S,Sanchez-Gonzalez V,Echavarria R,Mayaki D,Hussain SN

更新日期：2020-07-02 00:00:00

abstract：:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...

journal_title：Cells

authors： Huguet F,Flynn S,Vagnarelli P

更新日期：2019-07-07 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:SRC-3/AIB1 (Amplified in Breast Cancer-1) is a nuclear receptor coactivator for the estrogen receptor in breast cancer cells. It is also an intrinsically disordered protein when not engaged with transcriptional binding partners and degraded upon transcriptional coactivation. Given the amplified expression of SRC-3 in ...

journal_title：Cells

authors： Cabrita MA,Renart LI,Lau R,Pratt MAC

更新日期：2019-10-19 00:00:00

abstract：:Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...

journal_title：Cells

authors： Whitaker RH,Placzek WJ

更新日期：2019-04-12 00:00:00

abstract：:Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits ...

journal_title：Cells

authors： Gleue L,Schupp J,Zimmer N,Becker E,Frey H,Tuettenberg A,Helm M

更新日期：2020-09-29 00:00:00

abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...

journal_title：Cells

authors： Agrawal B,Gupta N,Vedi S,Singh S,Li W,Garg S,Li J,Kumar R

更新日期：2019-05-26 00:00:00

abstract：:A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-associated glucocort...

journal_title：Cells

authors： Hisaoka-Nakashima K,Azuma H,Ishikawa F,Nakamura Y,Wang D,Liu K,Wake H,Nishibori M,Nakata Y,Morioka N

更新日期：2020-04-25 00:00:00

abstract：:Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) represent important ...

journal_title：Cells

authors： Wali JA,Masters SL,Thomas HE

更新日期：2013-04-26 00:00:00

abstract：:Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...

journal_title：Cells

authors： Yen JH,Lin CY,Chuang CH,Chin HK,Wu MJ,Chen PY

更新日期：2020-04-03 00:00:00

abstract：:Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in order to stimulate cel...

journal_title：Cells

authors： Miyajima C,Kawarada Y,Inoue Y,Suzuki C,Mitamura K,Morishita D,Ohoka N,Imamura T,Hayashi H

更新日期：2020-01-09 00:00:00

abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...

journal_title：Cells

authors： Rutkowska E,Kwiecień I,Kulik K,Chełstowska B,Kłos K,Rzepecki P,Chciałowski A

更新日期：2021-01-06 00:00:00

abstract：:The Hippo pathway is a cellular signalling network, which plays major roles in organ homeostasis and development[...]. ...

journal_title：Cells

authors： Hansen CG

更新日期：2019-09-30 00:00:00

abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...

journal_title：Cells

authors： Legartová S,Lochmanová G,Zdráhal Z,Kozubek S,Šponer J,Krepl M,Pokorná P,Bártová E

更新日期：2019-09-17 00:00:00

abstract：:Microalgae have emerged as a promising platform for production of carbon- and energy- rich molecules, notably starch and oil. Establishing an economically viable algal biotechnology sector requires a holistic understanding of algal photosynthesis, physiology, cell cycle and metabolism. Starch/oil productivity is a com...

journal_title：Cells

authors： Burlacot A,Peltier G,Li-Beisson Y

更新日期：2019-09-26 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:White adipose tissue (WAT) lipolysis contributes to energy balance during fasting. Lipolysis can proceed by the sequential hydrolysis of triglycerides (TGs) by adipose triglyceride lipase (ATGL), then of diacylglycerols (DGs) by hormone-sensitive lipase (HSL). We showed that the combined genetic deficiency of ATGL and...

journal_title：Cells

authors： Zhang X,Zhang CC,Yang H,Soni KG,Wang SP,Mitchell GA,Wu JW

更新日期：2019-04-29 00:00:00

abstract：:During embryonic development, the heart undergoes complex morphogenesis from a liner tube into the four chambers consisting of ventricles, atria and valves. At the same time, the cardiomyocytes compact into a dense, aligned, and highly vascularized myocardium. The extracellular matrix (ECM) is known to play an importa...

journal_title：Cells

authors： Jallerat Q,Feinberg AW

更新日期：2020-01-24 00:00:00

abstract：:The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids, are acknowledged to be a better model of the in viv...

journal_title：Cells

authors： Demuynck R,Efimova I,Lin A,Declercq H,Krysko DV

更新日期：2020-03-13 00:00:00

abstract：:Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...

journal_title：Cells

authors： Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

更新日期：2020-12-03 00:00:00

abstract：:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...

journal_title：Cells

authors： Rogobete AF,Sandesc D,Bedreag OH,Papurica M,Popovici SE,Bratu T,Popoiu CM,Nitu R,Dragomir T,AAbed HIM,Ivan MV

更新日期：2018-12-13 00:00:00

abstract：:Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...

journal_title：Cells

authors： Duan TL,He GJ,Hu LD,Yan YB

更新日期：2019-08-05 00:00:00

abstract：:This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...

journal_title：Cells

authors： Broyles CN,Robinson P,Daniels MJ

更新日期：2018-05-31 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00