Abstract：
BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals that did not receive therapy; control with the introduction of culture medium concentrate (CM); introduction of MSCs (PL); introduction of CMPL. LRI modeling was performed on an X-ray machine at a dose of 110 Gy. Histological and immunohistochemical tests were performed. RESULTS:On the 112th day, the area of the open wound surface in the CMPL group was 6.7 times less than in the control group. Complete healing of the open wound surface of the skin in the CM group was observed in 40%, in CMPL 60%, in the PL group 20%, and in the C group there were no animals with a prolonged wound defect. A decrease in inflammatory processes was observed in the CMPL group. CONCLUSIONS:the use of a concentrate of conditioned MSCs (CMPL group) in severe LRI in laboratory animals accelerates the transition of the wound process to the stage of regeneration and epithelization.
journal_name
Cellsjournal_title
Cellsauthors
Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov Adoi
10.3390/cells9122558subject
Has Abstractpub_date
2020-11-29 00:00:00issue
12issn
2073-4409pii
cells9122558journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101133
更新日期：2019-09-24 00:00:00
abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040887
更新日期：2020-04-04 00:00:00
abstract：:More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061475
更新日期：2020-06-16 00:00:00
abstract：:Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA have not been elucidated. In the present work, we evaluated the effects and the mechanisms of IL-26 on M1 and M2 macrophage differentiation. Hu...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040938
更新日期：2020-04-10 00:00:00
abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102237
更新日期：2020-10-04 00:00:00
abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020122
更新日期：2019-02-03 00:00:00
abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122616
更新日期：2020-12-05 00:00:00
abstract：:Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102185
更新日期：2020-09-28 00:00:00
abstract：:Circulating tumor cells (CTCs) as real-time liquid biopsy [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9030661
更新日期：2020-03-09 00:00:00
abstract：:Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080909
更新日期：2019-08-16 00:00:00
abstract：:Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092142
更新日期：2020-09-22 00:00:00
abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells5020016
更新日期：2016-04-06 00:00:00
abstract：:The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091989
更新日期：2020-08-29 00:00:00
abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020390
更新日期：2020-02-07 00:00:00
abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In t...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7120245
更新日期：2018-12-05 00:00:00
abstract：:This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060051
更新日期：2018-05-31 00:00:00
abstract：:A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061377
更新日期：2020-06-01 00:00:00
abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080937
更新日期：2019-08-20 00:00:00
abstract：:Lyme Borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi that is transmitted through the bite of infected ticks. Both B cell-mediated humoral immunity and T cell immunity develop during natural Borrelia infection. However, compared with humoral immunity, the T cell response to Borrelia i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells2030607
更新日期：2013-09-13 00:00:00
abstract：:The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleuki...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051311
更新日期：2020-05-25 00:00:00
abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020271
更新日期：2020-01-22 00:00:00
abstract：:Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081833
更新日期：2020-08-04 00:00:00
abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080812
更新日期：2019-08-02 00:00:00
abstract：:The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030587
更新日期：2020-03-02 00:00:00
abstract：:The blood-brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of ti...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040851
更新日期：2020-04-01 00:00:00
abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1010015
更新日期：2012-03-21 00:00:00
abstract：:Mast cells are long-lived, granular, myeloid-derived leukocytes that have significant protective and repair functions in tissues. Mast cells sense disruptions in the local microenvironment and are first responders to physical, chemical and biological insults. When activated, mast cells release growth factors, protease...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122713
更新日期：2020-12-18 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111417
更新日期：2019-11-11 00:00:00
abstract：:Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in p...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010060
更新日期：2019-12-24 00:00:00
abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061483
更新日期：2020-06-18 00:00:00
