Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries.


BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals that did not receive therapy; control with the introduction of culture medium concentrate (CM); introduction of MSCs (PL); introduction of CMPL. LRI modeling was performed on an X-ray machine at a dose of 110 Gy. Histological and immunohistochemical tests were performed. RESULTS:On the 112th day, the area of the open wound surface in the CMPL group was 6.7 times less than in the control group. Complete healing of the open wound surface of the skin in the CM group was observed in 40%, in CMPL 60%, in the PL group 20%, and in the C group there were no animals with a prolonged wound defect. A decrease in inflammatory processes was observed in the CMPL group. CONCLUSIONS:the use of a concentrate of conditioned MSCs (CMPL group) in severe LRI in laboratory animals accelerates the transition of the wound process to the stage of regeneration and epithelization.






Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A




Has Abstract


2020-11-29 00:00:00












  • Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells.

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    pub_type: 杂志文章


    authors: Olea-Flores M,Zuñiga-Eulogio M,Tacuba-Saavedra A,Bueno-Salgado M,Sánchez-Carvajal A,Vargas-Santiago Y,Mendoza-Catalán MA,Pérez Salazar E,García-Hernández A,Padilla-Benavides T,Navarro-Tito N

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  • Microautophagy in Plants: Consideration of Its Molecular Mechanism.

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    pub_type: 杂志文章,评审


    authors: Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

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  • Inhibition of Transglutaminase 2 but Not of MDM2 Has a Significant Therapeutic Effect on Renal Cell Carcinoma.

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Guadagno NA,Progida C

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    authors: Holopainen M,Impola U,Lehenkari P,Laitinen S,Kerkelä E

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    authors: Rinkenbaugh AL,Baldwin AS

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    authors: Broyles CN,Robinson P,Daniels MJ

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Albakova Z,Armeev GA,Kanevskiy LM,Kovalenko EI,Sapozhnikov AM

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Willows S,Kulka M

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    pub_type: 杂志文章


    authors: Hu M,Bogoyevitch MA,Jans DA

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  • Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy.

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    pub_type: 杂志文章,评审


    authors: Yun CW,Kim HJ,Lim JH,Lee SH

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  • CDK12: A Potent Target and Biomarker for Human Cancer Therapy.

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    pub_type: 杂志文章,评审


    authors: Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

    更新日期:2020-06-18 00:00:00