Abstract:
:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-rich strand in yeast and human cells. Cells sense telomere length shortening and respond with cell cycle arrest at a certain size of telomeres referring to the "Hayflick limit." In addition to regulating the cell replicative senescence, telomere biology plays a fundamental role in regulating the chronological post-mitotic cell ageing. In this review, we summarize the current understandings of telomere regulation of cell replicative and chronological ageing in the pioneer model system Saccharomyces cerevisiae and provide an overview on telomere regulation of animal lifespans. We focus on the mechanisms of survivals by telomere elongation, DNA damage response and environmental factors in the absence of telomerase maintenance of telomeres in the yeast and mammals.
journal_name
Cellsjournal_title
Cellsauthors
Liu J,Wang L,Wang Z,Liu JPdoi
10.3390/cells8010054subject
Has Abstractpub_date
2019-01-15 00:00:00issue
1issn
2073-4409pii
cells8010054journal_volume
8pub_type
杂志文章,评审相关文献
Cells文献大全abstract::The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030723
更新日期:2020-03-15 00:00:00
abstract::The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091097
更新日期:2019-09-17 00:00:00
abstract::The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key proteins that generate (beta-secretase 1...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020452
更新日期:2020-02-17 00:00:00
abstract::Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and dif...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010025
更新日期:2020-12-25 00:00:00
abstract::The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091989
更新日期:2020-08-29 00:00:00
abstract::Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells1030346
更新日期:2012-07-27 00:00:00
abstract::Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092028
更新日期:2020-09-03 00:00:00
abstract::Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040984
更新日期:2020-04-16 00:00:00
abstract::Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081752
更新日期:2020-07-22 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071726
更新日期:2020-07-18 00:00:00
abstract::Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020359
更新日期:2020-02-04 00:00:00
abstract::BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030574
更新日期:2020-02-28 00:00:00
abstract::L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091039
更新日期:2019-09-05 00:00:00
abstract::Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020108
更新日期:2019-01-31 00:00:00
abstract::Microalgae have emerged as a promising platform for production of carbon- and energy- rich molecules, notably starch and oil. Establishing an economically viable algal biotechnology sector requires a holistic understanding of algal photosynthesis, physiology, cell cycle and metabolism. Starch/oil productivity is a com...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101154
更新日期:2019-09-26 00:00:00
abstract::One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080866
更新日期:2019-08-09 00:00:00
abstract::The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051076
更新日期:2020-04-26 00:00:00
abstract::Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...
journal_title:Cells
pub_type: 杂志文章,多中心研究
doi:10.3390/cells8121554
更新日期:2019-12-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051211
更新日期:2020-05-13 00:00:00
abstract::Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051102
更新日期:2020-04-29 00:00:00
abstract::The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been c...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020153
更新日期:2019-02-12 00:00:00
abstract::The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121543
更新日期:2019-11-29 00:00:00
abstract::Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040916
更新日期:2020-04-09 00:00:00
abstract::Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102204
更新日期:2020-09-29 00:00:00
abstract::CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals. To investigate the function of circ-FoxO3 in mouse myoblast cells' (C2C12) differentiation and proliferation, we used RT-qPCR to detect the expressi...
journal_title:Cells
pub_type: 杂志文章,收录出版
doi:10.3390/cells8060616
更新日期:2019-06-19 00:00:00
abstract::Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell's ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7120229
更新日期:2018-11-23 00:00:00
abstract::Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122554
更新日期:2020-11-28 00:00:00
abstract::Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081811
更新日期:2020-07-30 00:00:00
abstract::(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121577
更新日期:2019-12-05 00:00:00
abstract::Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030780
更新日期:2020-03-23 00:00:00