Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome.

abstract：:Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR rela...

journal_title：Cells

authors： Abo El-Khair SM,Arafa M,Besheer T,El-Eraky AM,Elsamanoudy AZ

更新日期：2018-10-25 00:00:00

abstract：:Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen synthesis. The eff...

journal_title：Cells

authors： Matilla L,Arrieta V,Jover E,Garcia-Peña A,Martinez-Martinez E,Sadaba R,Alvarez V,Navarro A,Fernandez-Celis A,Gainza A,Santamaria E,Fernandez-Irigoyen J,Rossignol P,Zannad F,Lopez-Andres N

更新日期：2020-07-10 00:00:00

abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...

journal_title：Cells

authors： Okamoto T,Kawamoto E,Usuda H,Tanaka T,Nikai T,Asanuma K,Suzuki K,Shimaoka M,Wada K

更新日期：2020-07-30 00:00:00

abstract：:The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...

journal_title：Cells

authors： Zhang L,Ye Y,Dhar R,Deng J,Tang H

更新日期：2019-10-21 00:00:00

abstract：:Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes ...

journal_title：Cells

authors： Happé C,Kurakula K,Sun XQ,da Silva Goncalves Bos D,Rol N,Guignabert C,Tu L,Schalij I,Wiesmeijer KC,Tura-Ceide O,Vonk Noordegraaf A,de Man FS,Bogaard HJ,Goumans MJ

更新日期：2020-06-08 00:00:00

abstract：:TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia. Here we investigated the role of TonEBP in acute kidney injury (AKI) using a line of TonEBP haplo-deficient mice s...

journal_title：Cells

authors： Yoo EJ,Lim SW,Kang HJ,Park H,Yoon S,Nam D,Sanada S,Kwon MJ,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2019-10-20 00:00:00

abstract：:Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation, adhesion, morphology, exocytosis, and gene expression. As a result,...

journal_title：Cells

authors： Beck EM,Parnell E,Cowley A,Porter A,Gillespie J,Robinson J,Robinson L,Pannifer AD,Hamon V,Jones P,Morrison A,McElroy S,Timmerman M,Rutjes H,Mahajan P,Wiejak J,Luchowska-Stańska U,Morgan D,Barker G,Rehmann H,Yarwoo

更新日期：2019-11-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanisms involved in the neurodegenerative process in ALS have been found, ...

journal_title：Cells

authors： Vicencio E,Beltrán S,Labrador L,Manque P,Nassif M,Woehlbier U

更新日期：2020-02-07 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...

journal_title：Cells

authors： Largeot A,Pagano G,Gonder S,Moussay E,Paggetti J

更新日期：2019-05-13 00:00:00

abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...

journal_title：Cells

authors： Fischer I,Nickel AC,Qin N,Taban K,Pauck D,Steiger HJ,Kamp M,Muhammad S,Hänggi D,Fritsche E,Remke M,Kahlert UD

更新日期：2020-12-15 00:00:00

abstract：:HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...

journal_title：Cells

authors： Van Belle S,El Ashkar S,Čermáková K,Matthijssens F,Goossens S,Canella A,Hodges CH,Christ F,De Rijck J,Van Vlierberghe P,Veverka V,Debyser Z

更新日期：2021-01-19 00:00:00

abstract：:There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...

journal_title：Cells

authors： Wilson H,Politis M,Rabiner EA,Middleton LT

更新日期：2020-12-02 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...

journal_title：Cells

authors： Hu M,Bogoyevitch MA,Jans DA

更新日期：2019-11-11 00:00:00

abstract：:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...

journal_title：Cells

authors： Huda N,Xu Y,Bates AM,Rankin DA,Kannan N,Gilley D

更新日期：2019-05-04 00:00:00

abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...

journal_title：Cells

authors： Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

更新日期：2019-08-13 00:00:00

abstract：:The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes reportedly share with circular RNAs (circRNAs). Interestingly, some ...

journal_title：Cells

authors： Mfossa ACM,Thekkekara Puthenparampil H,Inalegwu A,Coolkens A,Baatout S,Benotmane MA,Huylebroeck D,Quintens R

更新日期：2019-07-26 00:00:00

abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...

journal_title：Cells

authors： Sun Y,Cai Y,Zang QS

更新日期：2019-02-10 00:00:00

abstract：:Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogen...

journal_title：Cells

authors： Rampogu S,Baek A,Park C,Parate S,Parameswaran S,Park Y,Shaik B,Kim JH,Park SJ,Lee KW

更新日期：2019-03-21 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...

journal_title：Cells

authors： Samak M,Hinkel R

更新日期：2019-11-27 00:00:00

abstract：:The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is known that CFTR exit from the ER is mediated by specific retention/so...

journal_title：Cells

authors： Santos JD,Canato S,Carvalho AS,Botelho HM,Aloria K,Amaral MD,Matthiesen R,Falcao AO,Farinha CM

更新日期：2019-04-14 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) from various sources exhibit different potential for stemness and therapeutic abilities. Recently, we reported a unique MSCs from human palatine tonsil (TMSCs) and their superior proliferation capacity compared to MSCs from other sources. However, unique characteristics of each MSC are...

journal_title：Cells

authors： Seo Y,Shin TH,Ahn JS,Oh SJ,Shin YY,Yang JW,Park HY,Shin SC,Kwon HK,Kim JM,Sung ES,Park GC,Lee BJ,Kim HS

更新日期：2020-03-06 00:00:00

abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...

journal_title：Cells

authors： Olea-Flores M,Zuñiga-Eulogio M,Tacuba-Saavedra A,Bueno-Salgado M,Sánchez-Carvajal A,Vargas-Santiago Y,Mendoza-Catalán MA,Pérez Salazar E,García-Hernández A,Padilla-Benavides T,Navarro-Tito N

更新日期：2019-09-24 00:00:00

abstract：:Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic intracellular microbes. Autophagy is a dynamic process in which the diffe...

journal_title：Cells

authors： Domínguez-Martín E,Cardenal-Muñoz E,King JS,Soldati T,Coria R,Escalante R

更新日期：2017-07-03 00:00:00

abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...

journal_title：Cells

authors： Riboni L,Abdel Hadi L,Navone SE,Guarnaccia L,Campanella R,Marfia G

更新日期：2020-02-01 00:00:00

abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...

journal_title：Cells

authors： Ji W,Rivero F

更新日期：2016-06-14 00:00:00

abstract：:Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...

journal_title：Cells

authors： Vital SA,Senchenkova EY,Ansari J,Gavins FNE

更新日期：2020-11-13 00:00:00

abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...

journal_title：Cells

authors： Bécot A,Pardossi-Piquard R,Bourgeois A,Duplan E,Xiao Q,Diwan A,Lee JM,Lauritzen I,Checler F

更新日期：2020-05-12 00:00:00