Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks.

abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...

journal_title：Cells

authors： Trstenjak Prebanda M,Završnik J,Turk B,Kopitar Jerala N

更新日期：2019-11-21 00:00:00

abstract：:Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of t...

journal_title：Cells

authors： Al-Rashed F,Alghaith A,Azim R,AlMekhled D,Thomas R,Sindhu S,Ahmad R

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...

journal_title：Cells

authors： Ritter K,Sodenkamp JC,Hölscher A,Behrends J,Hölscher C

更新日期：2020-12-22 00:00:00

abstract：:Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...

journal_title：Cells

authors： Uslu Ö,Herold J,Kanse SM

更新日期：2019-11-06 00:00:00

abstract：:Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...

journal_title：Cells

authors： Oechslin N,Moradpour D,Gouttenoire J

更新日期：2020-05-22 00:00:00

abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...

journal_title：Cells

authors： Ogiwara K,Takahashi T

更新日期：2019-03-04 00:00:00

abstract：:Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, ...

journal_title：Cells

authors： Moore G,Annett S,McClements L,Robson T

更新日期：2020-06-20 00:00:00

abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...

journal_title：Cells

authors： Mondello S,Guedes VA,Lai C,Czeiter E,Amrein K,Kobeissy F,Mechref Y,Jeromin A,Mithani S,Martin C,Wagner CL,Czigler A,Tóth L,Fazekas B,Buki A,Gill J

更新日期：2020-04-15 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00

abstract：:High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...

journal_title：Cells

authors： Liu Q,Junker A,Murakami K,Hu P

更新日期：2019-09-02 00:00:00

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatric diseases, where study subjects are almost exclusively children...

journal_title：Cells

authors： Faresjö M

更新日期：2012-05-29 00:00:00

abstract：:A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...

journal_title：Cells

authors： Tröger J,Hoischen C,Perner B,Monajembashi S,Barbotin A,Löschberger A,Eggeling C,Kessels MM,Qualmann B,Hemmerich P

更新日期：2020-06-01 00:00:00

abstract：:Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

journal_title：Cells

authors： Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

更新日期：2019-06-30 00:00:00

abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...

journal_title：Cells

authors： Héraud C,Pinault M,Lagrée V,Moreau V

更新日期：2019-04-12 00:00:00

abstract：:Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...

journal_title：Cells

authors： Barrault L,Gide J,Qing T,Lesueur L,Tost J,Denis JA,Cailleret M,Aubry L,Peschanski M,Martinat C,Baghdoyan S

更新日期：2019-11-26 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00

abstract：:Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...

journal_title：Cells

authors： Hong CT,Chen KY,Wang W,Chiu JY,Wu D,Chao TY,Hu CJ,Chau KD,Bamodu OA

更新日期：2020-03-17 00:00:00

abstract：:Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

journal_title：Cells

authors： Frey K,Pucker B

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...

journal_title：Cells

authors： Agranovsky A

更新日期：2021-01-07 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in the proteasome, mediated by three types of ubiquitin enzymes: E1...

journal_title：Cells

authors： Su T,Yang M,Wang P,Zhao Y,Ma C

更新日期：2020-10-01 00:00:00

abstract：:The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...

journal_title：Cells

authors： Bublitz K,Böckmann S,Peters K,Hinz B

更新日期：2020-10-15 00:00:00

abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...

journal_title：Cells

authors： Kaluzki I,Hailemariam-Jahn T,Doll M,Kaufmann R,Balermpas P,Zöller N,Kippenberger S,Meissner M

更新日期：2019-10-28 00:00:00

abstract：:Drug screening-i.e., testing the effects of a number of drugs in multiple cell lines-is used for drug discovery and development, and can also be performed to evaluate the heterogeneity of a disease entity. Notably, intertumoral heterogeneity is a large hurdle to overcome for establishing standard cancer treatment, nec...

journal_title：Cells

authors： Kondo J,Inoue M

更新日期：2019-05-17 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...

journal_title：Cells

authors： Pant K,Peixoto E,Richard S,Gradilone SA

更新日期：2020-03-23 00:00:00

abstract：:Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...

journal_title：Cells

authors： Nashine S,Kenney MC

更新日期：2020-04-29 00:00:00