Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives.

abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

journal_title：Cells

authors： Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

更新日期：2020-08-18 00:00:00

abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

journal_title：Cells

authors： Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

更新日期：2019-05-08 00:00:00

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...

journal_title：Cells

authors： Huda N,Xu Y,Bates AM,Rankin DA,Kannan N,Gilley D

更新日期：2019-05-04 00:00:00

abstract：:Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...

journal_title：Cells

authors： Barrault L,Gide J,Qing T,Lesueur L,Tost J,Denis JA,Cailleret M,Aubry L,Peschanski M,Martinat C,Baghdoyan S

更新日期：2019-11-26 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00

abstract：:Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...

journal_title：Cells

authors： Vital SA,Senchenkova EY,Ansari J,Gavins FNE

更新日期：2020-11-13 00:00:00

abstract：:Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell typ...

journal_title：Cells

authors： Santos J,Hubert T,Milthorpe BK

更新日期：2020-03-04 00:00:00

abstract：:Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein ...

journal_title：Cells

authors： Gallego P,Castejón-Vega B,Del Campo JA,Cordero MD

更新日期：2020-09-23 00:00:00

abstract：:The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their ro...

journal_title：Cells

authors： Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini A

更新日期：2014-08-05 00:00:00

abstract：:Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...

journal_title：Cells

authors： Yen JH,Lin CY,Chuang CH,Chin HK,Wu MJ,Chen PY

更新日期：2020-04-03 00:00:00

abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...

journal_title：Cells

authors： Kolb K,Hellinger J,Kansy M,Wegwitz F,Bauerschmitz G,Emons G,Gründker C

更新日期：2020-12-05 00:00:00

abstract：:Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. Th...

journal_title：Cells

authors： Smith E,Palethorpe HM,Tomita Y,Pei JV,Townsend AR,Price TJ,Young JP,Yool AJ,Hardingham JE

更新日期：2018-07-21 00:00:00

abstract：:HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...

journal_title：Cells

authors： Van Belle S,El Ashkar S,Čermáková K,Matthijssens F,Goossens S,Canella A,Hodges CH,Christ F,De Rijck J,Van Vlierberghe P,Veverka V,Debyser Z

更新日期：2021-01-19 00:00:00

abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...

journal_title：Cells

authors： Monteonofrio L,Valente D,Rinaldo C,Soddu S

更新日期：2019-11-05 00:00:00

abstract：:Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear functional domains. We performed limited proteolysis followed by ...

journal_title：Cells

authors： Sztacho M,Šalovská B,Červenka J,Balaban C,Hoboth P,Hozák P

更新日期：2021-01-04 00:00:00

abstract：:Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progress...

journal_title：Cells

authors： Valencia J,M Fernández-Sevilla L,Fraile-Ramos A,Sacedón R,Jiménez E,Vicente A,Varas A

更新日期：2019-07-14 00:00:00

abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...

journal_title：Cells

authors： Mederos Y Schnitzler M,Gudermann T,Storch U

更新日期：2018-11-20 00:00:00

abstract：:Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...

journal_title：Cells

authors： Heeke S,Mograbi B,Alix-Panabières C,Hofman P

更新日期：2019-07-13 00:00:00

abstract：:Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...

journal_title：Cells

authors： Sioud F,Amor S,Toumia IB,Lahmar A,Aires V,Chekir-Ghedira L,Delmas D

更新日期：2020-02-04 00:00:00

abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...

journal_title：Cells

authors： Bonafede R,Brandi J,Manfredi M,Scambi I,Schiaffino L,Merigo F,Turano E,Bonetti B,Marengo E,Cecconi D,Mariotti R

更新日期：2019-09-14 00:00:00

abstract：:The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been c...

journal_title：Cells

authors： Girardi D,Barrichello A,Fernandes G,Pereira A

更新日期：2019-02-12 00:00:00

abstract：:The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...

journal_title：Cells

authors： Wai KC,Strohl MP,van Zante A,Ha PK

更新日期：2020-02-22 00:00:00

abstract：:Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...

journal_title：Cells

authors： Tan Q,Shi S,Liang J,Zhang X,Cao D,Wang Z

更新日期：2020-03-06 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...

journal_title：Cells

authors： Akil AA,Jerman LF,Yassin E,Padmajeya SS,Al-Kurbi A,Fakhro KA

更新日期：2020-11-03 00:00:00

abstract：:Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...

journal_title：Cells

authors： Huang Y,Yi X,Kang C,Wu C

更新日期：2019-10-16 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:Nitric oxide (NO) is an important mediator of inflammation response and the production of NO has been linked to a variety of diseases, including tumors, inflammation and central nervous system diseases. In macrophages, a high level of NO is generated by iNOS during inflammatory responses triggered by cytokines or path...

journal_title：Cells

authors： Wang J,Wu MY,Su H,Lu J,Chen X,Tan J,Lu JH

更新日期：2019-10-15 00:00:00

abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...

journal_title：Cells

authors： Sun Y,Cai Y,Zang QS

更新日期：2019-02-10 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00