Abstract：
:Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However, failure to accurately mimic intrinsic glucose regulation results in glucose fluctuations and long-term complications impacting key organs such as the heart, kidneys, and/or the eyes. It is well established that genetic and environmental factors contribute to the initiation and progression of T1D, but recent studies show that epigenetic modifications are also important. Here, we discuss key epigenetic modifications associated with T1D pathogenesis and discuss how recent research is finding ways to harness epigenetic mechanisms to prevent, reverse, or manage T1D.
journal_name
Cellsjournal_title
Cellsauthors
Akil AA,Jerman LF,Yassin E,Padmajeya SS,Al-Kurbi A,Fakhro KAdoi
10.3390/cells9112403subject
Has Abstractpub_date
2020-11-03 00:00:00issue
11issn
2073-4409pii
cells9112403journal_volume
9pub_type
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