Abstract：
:Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew M1-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells.
journal_name
Cellsjournal_title
Cellsauthors
Valencia J,M Fernández-Sevilla L,Fraile-Ramos A,Sacedón R,Jiménez E,Vicente A,Varas Adoi
10.3390/cells8070722subject
Has Abstractpub_date
2019-07-14 00:00:00issue
7issn
2073-4409pii
cells8070722journal_volume
8pub_type
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