Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells.

abstract：:Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Du...

journal_title：Cells

authors： Lee JE,Cranna NJ,Chahal AS,Quinn LM

更新日期：2012-12-05 00:00:00

abstract：:Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been f...

journal_title：Cells

authors： Stackhouse CT,Gillespie GY,Willey CD

更新日期：2020-10-28 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00

abstract：:In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. Here, we...

journal_title：Cells

authors： Chenevert J,Roca M,Besnardeau L,Ruggiero A,Nabi D,McDougall A,Copley RR,Christians E,Castagnetti S

更新日期：2020-04-28 00:00:00

abstract：:The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...

journal_title：Cells

authors： Fraschini R

更新日期：2020-01-22 00:00:00

abstract：:The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids, are acknowledged to be a better model of the in viv...

journal_title：Cells

authors： Demuynck R,Efimova I,Lin A,Declercq H,Krysko DV

更新日期：2020-03-13 00:00:00

abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...

journal_title：Cells

authors： Kaluzki I,Hailemariam-Jahn T,Doll M,Kaufmann R,Balermpas P,Zöller N,Kippenberger S,Meissner M

更新日期：2019-10-28 00:00:00

abstract：:One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research...

journal_title：Cells

authors： Hasanovic A,Mus-Veteau I

更新日期：2018-08-14 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation and the scavenging of reactive species...

journal_title：Cells

authors： Caruso G,Fresta CG,Musso N,Giambirtone M,Grasso M,Spampinato SF,Merlo S,Drago F,Lazzarino G,Sortino MA,Lunte SM,Caraci F

更新日期：2019-01-17 00:00:00

abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...

journal_title：Cells

authors： Lapitz A,Arbelaiz A,O'Rourke CJ,Lavin JL,Casta A,Ibarra C,Jimeno JP,Santos-Laso A,Izquierdo-Sanchez L,Krawczyk M,Perugorria MJ,Jimenez-Aguero R,Sanchez-Campos A,Riaño I,Gónzalez E,Lammert F,Marzioni M,Macias RIR,Marin

更新日期：2020-03-14 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00

abstract：:Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...

journal_title：Cells

authors： Fernandes J,Miranda RL,de Lemos ERS,Guterres A

更新日期：2020-11-23 00:00:00

abstract：:We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D bioprinting of conductive scaffolds. The 3D printability of conductive inks was evaluated in terms of their rheological properties. The differentiati...

journal_title：Cells

authors： Bordoni M,Karabulut E,Kuzmenko V,Fantini V,Pansarasa O,Cereda C,Gatenholm P

更新日期：2020-03-11 00:00:00

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00

abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

journal_title：Cells

authors： Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

更新日期：2020-02-26 00:00:00

abstract：:Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...

journal_title：Cells

authors： Konno T,Melo EP,Chambers JE,Avezov E

更新日期：2021-01-25 00:00:00

abstract：:MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and n...

journal_title：Cells

authors： Ala U

更新日期：2020-06-28 00:00:00

abstract：:(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...

journal_title：Cells

authors： Bonig H,Kuçi Z,Kuçi S,Bakhtiar S,Basu O,Bug G,Dennis M,Greil J,Barta A,Kállay KM,Lang P,Lucchini G,Pol R,Schulz A,Sykora KW,Teichert von Luettichau I,Herter-Sprie G,Ashab Uddin M,Jenkin P,Alsultan A,Buechner J,S

更新日期：2019-12-05 00:00:00

abstract：:Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...

journal_title：Cells

authors： Duan TL,He GJ,Hu LD,Yan YB

更新日期：2019-08-05 00:00:00

abstract：:Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 signaling axis is known to play a role in PD-like neuropathology, the molecular mechanisms that govern this process remain poorly understood. Herein, we show ...

journal_title：Cells

authors： Samidurai M,Tarale P,Janarthanam C,Estrada CG,Gordon R,Zenitsky G,Jin H,Anantharam V,Kanthasamy AG,Kanthasamy A

更新日期：2020-08-04 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1-5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its vasoconstrictor effects. We aimed to separate the beneficial and potentially de...

journal_title：Cells

authors： Wafa D,Koch N,Kovács J,Kerék M,Proia RL,Tigyi GJ,Benyó Z,Miklós Z

更新日期：2020-07-24 00:00:00

abstract：:Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...

journal_title：Cells

authors： Uslu Ö,Herold J,Kanse SM

更新日期：2019-11-06 00:00:00

abstract：:The finding that transcription occurs at chromosome ends has opened new fields of study on the roles of telomeric transcripts in chromosome end maintenance and genome stability. Indeed, the ends of chromosomes are required to be protected from activation of DNA damage response and DNA repair pathways. Chromosome end p...

journal_title：Cells

authors： Bettin N,Oss Pegorar C,Cusanelli E

更新日期：2019-03-15 00:00:00

abstract：:The primary cilium is an organelle involved in cellular signalling. Mutations affecting proteins involved in cilia assembly or function result in diseases known as ciliopathies, which cause a wide variety of phenotypes across multiple tissues. These mutations disrupt various cellular processes, including regulation of...

journal_title：Cells

authors： Collins I,Wann AKT

更新日期：2020-01-23 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...

journal_title：Cells

authors： Reddy PH,Oliver DM

更新日期：2019-05-22 00:00:00

abstract：:There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...

journal_title：Cells

authors： Harrell CR,Jovicic N,Djonov V,Arsenijevic N,Volarevic V

更新日期：2019-12-11 00:00:00

abstract：:Insulin secretion from the β-cells of the islets of Langerhans is triggered mainly by nutrients such as glucose, and incretin hormones such as glucagon-like peptide-1 (GLP-1). The mechanisms of the stimulus-secretion coupling involve the participation of the key enzymes that metabolize the nutrients, and numerous ion ...

journal_title：Cells

authors： Islam MS

更新日期：2020-03-11 00:00:00

abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

journal_title：Cells

authors： Laronha H,Caldeira J

更新日期：2020-04-26 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00