Abstract：
:The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their role in controlling the different pathways regulating cell identity and fate determination. In particular, we will focus on the involvement of miRNAs in pluripotency determination and reprogramming, and specifically on cardiac lineage commitment and cell direct transdifferentiation into cardiomyocytes. The identification of cardiac-specific miRNAs and their targets provide new promising insights into the mechanisms that regulate cardiac development, function and dysfunction. Furthermore, due to their contribution in reprogramming, they could offer new opportunities for developing safe and efficient cell-based therapies for cardiovascular disorders.
journal_name
Cellsjournal_title
Cellsauthors
Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini Adoi
10.3390/cells3030802subject
Has Abstractpub_date
2014-08-05 00:00:00pages
802-23issue
3issn
2073-4409pii
cells3030802journal_volume
3pub_type
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