TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision.

abstract：:Non-human primates (NHP) are important surrogate models for late preclinical development of advanced therapy medicinal products (ATMPs), including induced pluripotent stem cell (iPSC)-based therapies, which are also under development for heart failure repair. For effective heart repair by remuscularization, large numb...

journal_title：Cells

authors： Stauske M,Rodriguez Polo I,Haas W,Knorr DY,Borchert T,Streckfuss-Bömeke K,Dressel R,Bartels I,Tiburcy M,Zimmermann WH,Behr R

更新日期：2020-05-29 00:00:00

abstract：:Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate...

journal_title：Cells

authors： Drechsler Y,Vasconcelos EJR,Griggs LM,Diniz PPPV,Collisson E

更新日期：2020-06-09 00:00:00

abstract：:Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...

journal_title：Cells

authors： Whitaker RH,Placzek WJ

更新日期：2019-04-12 00:00:00

abstract：:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...

journal_title：Cells

authors： Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo E

更新日期：2020-04-22 00:00:00

abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...

journal_title：Cells

authors： Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi C

更新日期：2019-12-01 00:00:00

abstract：:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...

journal_title：Cells

authors： Cha YJ,Koo JS

更新日期：2020-07-27 00:00:00

abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

journal_title：Cells

authors： Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

更新日期：2020-08-18 00:00:00

abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...

journal_title：Cells

authors： Legartová S,Lochmanová G,Zdráhal Z,Kozubek S,Šponer J,Krepl M,Pokorná P,Bártová E

更新日期：2019-09-17 00:00:00

abstract：:The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...

journal_title：Cells

authors： Paluszczak J

更新日期：2020-03-15 00:00:00

abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...

journal_title：Cells

authors： Laferrière F,He X,Zinghirino F,Doudnikoff E,Faggiani E,Meissner WG,Bezard E,De Giorgi F,Ichas F

更新日期：2020-10-29 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...

journal_title：Cells

authors： Kang JH,Lee SH,Lee JS,Oh SJ,Ha JS,Choi HJ,Kim SY

更新日期：2020-06-16 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed. It is also known to be linked with several aspects of tumor malignancy in some types of human tumors, including invasion, metastasis, and cancer stemness. However, there are few reports on the expression of dog PDPN (dPDPN) in ...

journal_title：Cells

authors： Shinada M,Kato D,Kamoto S,Yoshimoto S,Tsuboi M,Yoshitake R,Eto S,Ikeda N,Saeki K,Hashimoto Y,Takahashi Y,Chambers J,Uchida K,Kaneko MK,Fujita N,Nishimura R,Kato Y,Nakagawa T

更新日期：2020-05-05 00:00:00

abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...

journal_title：Cells

authors： Dimitrova-Shumkovska J,Krstanoski L,Veenman L

更新日期：2020-04-02 00:00:00

abstract：:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a...

journal_title：Cells

authors： Adu-Agyeiwaah Y,Grant MB,Obukhov AG

更新日期：2020-11-23 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...

journal_title：Cells

authors： Sgarbi G,Gorini G,Liuzzi F,Solaini G,Baracca A

更新日期：2018-06-21 00:00:00

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...

journal_title：Cells

authors： Monteonofrio L,Valente D,Rinaldo C,Soddu S

更新日期：2019-11-05 00:00:00

abstract：:Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

journal_title：Cells

authors： Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

更新日期：2020-02-24 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...

journal_title：Cells

authors： Hu M,Bogoyevitch MA,Jans DA

更新日期：2019-11-11 00:00:00

abstract：:The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...

journal_title：Cells

authors： Shukla E,Chauhan R

更新日期：2019-09-27 00:00:00

abstract：:Skin models with efficient skin barrier function are required for percutaneous absorption studies. The contribution of media supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) to the development of the skin barrier function of in vitro skin models remains incompletely understood. To investigate wheth...

journal_title：Cells

authors： Simard M,Julien P,Fradette J,Pouliot R

更新日期：2019-09-25 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...

journal_title：Cells

authors： Cheng X,Li L,Shi G,Chen L,Fang C,Li M,Li C

更新日期：2020-02-15 00:00:00

abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

journal_title：Cells

authors： Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

更新日期：2020-07-15 00:00:00

abstract：:Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastom...

journal_title：Cells

authors： Karatsai O,Shliaha P,Jensen ON,Stasyk O,Rędowicz MJ

更新日期：2020-09-30 00:00:00

abstract：:Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. Th...

journal_title：Cells

authors： Smith E,Palethorpe HM,Tomita Y,Pei JV,Townsend AR,Price TJ,Young JP,Yool AJ,Hardingham JE

更新日期：2018-07-21 00:00:00