A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment.

Abstract:

:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.

journal_name

Cells

journal_title

Cells

authors

Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo E

doi

10.3390/cells9041043

subject

Has Abstract

pub_date

2020-04-22 00:00:00

issue

4

issn

2073-4409

pii

cells9041043

journal_volume

9

pub_type

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