Abstract:
:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.
journal_name
Cellsjournal_title
Cellsauthors
Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo Edoi
10.3390/cells9041043subject
Has Abstractpub_date
2020-04-22 00:00:00issue
4issn
2073-4409pii
cells9041043journal_volume
9pub_type
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