Abstract:
:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degeneration (AMD) and Sorsby fundus dystrophy, and potentially, through indirect mechanisms, with Alzheimer's disease. Insights into TIMP-3 activities may be gleaned from studying Sorsby-linked mutations. However, recent findings do not fully support the prevailing hypothesis that a gain of function through the dimerisation of mutated TIMP-3 is responsible for retinopathy. Findings from Alzheimer's patients suggest a hitherto poorly studied relationship between TIMP-3 and the Alzheimer's-linked amyloid-beta (A) proteins that warrant further scrutiny. This may also have implications for understanding AMD as aged/diseased retinae contain high levels of A. Findings from TIMP-3 knockout and mutant knock-in mice have not led to new treatments, particularly as the latter does not satisfactorily recapitulate the Sorsby phenotype. However, recent advances in stem cell and in vitro approaches offer novel insights into understanding TIMP-3 pathology in the retina-brain axis, which has so far not been collectively examined. We propose that TIMP-3 activities could extend beyond its hitherto supposed functions to cause age-related changes and disease in these organs.
journal_name
Cellsjournal_title
Cellsauthors
Dewing JM,Carare RO,Lotery AJ,Ratnayaka JAdoi
10.3390/cells9010039subject
Has Abstractpub_date
2019-12-21 00:00:00issue
1issn
2073-4409pii
cells9010039journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract::T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050504
更新日期:2019-05-24 00:00:00
abstract::The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive (ER+) breast cancer (BC) patients. The aim of this study was to analyze if the biological aggressiveness, underlined in ER+ BC tumors with higher AR/ER ratio, co...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9041064
更新日期:2020-04-24 00:00:00
abstract::Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050415
更新日期:2019-05-05 00:00:00
abstract::Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070669
更新日期:2019-07-02 00:00:00
abstract::Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. Th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7070081
更新日期:2018-07-21 00:00:00
abstract::Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040887
更新日期:2020-04-04 00:00:00
abstract::Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060618
更新日期:2019-06-20 00:00:00
abstract::In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated a...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071581
更新日期:2020-06-29 00:00:00
abstract::Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...
journal_title:Cells
pub_type: 临床试验,杂志文章
doi:10.3390/cells8030237
更新日期:2019-03-12 00:00:00
abstract::Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111396
更新日期:2019-11-06 00:00:00
abstract::L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091039
更新日期:2019-09-05 00:00:00
abstract::Wnt/β-catenin signaling plays vital role in the regulation of cellular proliferation, migration, stem cells cell renewal and genetic stability. This pathway is crucial during the early developmental process; however, the distinct role of Wnt/β-catenin signaling during pre-implantation period of bovine embryonic develo...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040923
更新日期:2020-04-09 00:00:00
abstract::The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020500
更新日期:2020-02-22 00:00:00
abstract::Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030659
更新日期:2020-03-09 00:00:00
abstract::Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010016
更新日期:2020-12-24 00:00:00
abstract::Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells2010163
更新日期:2013-03-14 00:00:00
abstract::Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic in...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061340
更新日期:2020-05-27 00:00:00
abstract::Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010101
更新日期:2021-01-08 00:00:00
abstract::(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121616
更新日期:2019-12-11 00:00:00
abstract::Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030780
更新日期:2020-03-23 00:00:00
abstract::Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111329
更新日期:2019-10-28 00:00:00
abstract::In 2011, I was invited to serve as the Editor-In-Chief for Cells, which back then was a "new kid on the block" among open access (OA) journals.[...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells6040041
更新日期:2017-11-01 00:00:00
abstract::The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaini...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071678
更新日期:2020-07-13 00:00:00
abstract::Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121633
更新日期:2019-12-13 00:00:00
abstract::Nicotinamide (NAM), the amide form of vitamin B3, plays pivotal roles in regulating various cellular processes including energy production and maintenance of genomic stability. The current study aimed at deciphering the effect of NAM, when administered during in vitro maturation (IVM), on the developmental competence ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061550
更新日期:2020-06-25 00:00:00
abstract::Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122554
更新日期:2020-11-28 00:00:00
abstract::This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060051
更新日期:2018-05-31 00:00:00
abstract::Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030524
更新日期:2020-02-25 00:00:00
abstract::Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080893
更新日期:2019-08-14 00:00:00
abstract::Circulating tumor cells (CTCs) as real-time liquid biopsy [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells9030661
更新日期:2020-03-09 00:00:00