"Circulating Tumor Cells: Finding Rare Events for a Huge Knowledge of Cancer Dissemination".

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...

journal_title：Cells

authors： Kim YS,Choi J,Yoon BE

更新日期：2020-09-27 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...

journal_title：Cells

authors： Kosyna FK,Depping R

更新日期：2018-11-21 00:00:00

abstract：:Myelination of neuronal axons is essential for proper brain functioning and requires mature myelinating oligodendrocytes (myOLs). The human OL cell lines HOG and MO3.13 have been widely used as in vitro models to study OL (dys) functioning. Here we applied a number of protocols aimed at differentiating HOG and MO3.13 ...

journal_title：Cells

authors： De Kleijn KMA,Zuure WA,Peijnenborg J,Heuvelmans JM,Martens GJM

更新日期：2019-09-17 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...

journal_title：Cells

authors： Bolívar S,Navarro X,Udina E

更新日期：2020-09-20 00:00:00

abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...

journal_title：Cells

authors： Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

更新日期：2019-08-13 00:00:00

abstract：:Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they fa...

journal_title：Cells

authors： Xuan P,Pan S,Zhang T,Liu Y,Sun H

更新日期：2019-08-30 00:00:00

abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...

journal_title：Cells

authors： Héraud C,Pinault M,Lagrée V,Moreau V

更新日期：2019-04-12 00:00:00

abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...

journal_title：Cells

authors： Fossati G,Matteoli M,Menna E

更新日期：2020-09-26 00:00:00

abstract：:Although del Río-Hortega originally reported that leptomeningeal cells are the source of ramified microglia in the developing brain, recent views do not seem to pay much attention to this notion. In this study, in vitro experiments were conducted to determine whether leptomeninges generate ramified microglia. The lept...

journal_title：Cells

authors： Tanaka J,Takahashi H,Yano H,Nakanishi H

更新日期：2020-12-25 00:00:00

abstract：:The authors wish to make the following erratum to this paper [1].[...]. ...

journal_title：Cells

authors： Lazar-Karsten P,Belge G,Schult-Badusche D,Focken T,Radtke A,Yan J,Ranabhat P,Mohamed SA

更新日期：2016-09-20 00:00:00

abstract：:Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Escherichia coli (E. coli) has long been a popular model organism for basic biological research. In this paper, weighted gene co-expression network analysis (WGCNA) algorithm was ap...

journal_title：Cells

authors： Liu W,Li L,Long X,You W,Zhong Y,Wang M,Tao H,Lin S,He H

更新日期：2018-03-08 00:00:00

abstract：:Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably by annexins (Anx) is critical for membrane repair. We applied me...

journal_title：Cells

authors： Croissant C,Gounou C,Bouvet F,Tan S,Bouter A

更新日期：2020-07-21 00:00:00

abstract：:The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut glioma, limiting the discovery of new effective chemotherapeutic agen...

journal_title：Cells

authors： Dao Trong P,Jungwirth G,Yu T,Pusch S,Unterberg A,Herold-Mende C,Warta R

更新日期：2020-06-03 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:Drug screening-i.e., testing the effects of a number of drugs in multiple cell lines-is used for drug discovery and development, and can also be performed to evaluate the heterogeneity of a disease entity. Notably, intertumoral heterogeneity is a large hurdle to overcome for establishing standard cancer treatment, nec...

journal_title：Cells

authors： Kondo J,Inoue M

更新日期：2019-05-17 00:00:00

abstract：:Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...

journal_title：Cells

authors： Navarro-Romero A,Montpeyó M,Martinez-Vicente M

更新日期：2020-11-02 00:00:00

abstract：:Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...

journal_title：Cells

authors： Mélik Parsadaniantz S,Réaux-le Goazigo A,Sapienza A,Habas C,Baudouin C

更新日期：2020-02-25 00:00:00

abstract：:Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...

journal_title：Cells

authors： Sousa L,Pankonien I,Clarke LA,Silva I,Kunzelmann K,Amaral MD

更新日期：2020-07-02 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...

journal_title：Cells

authors： Vaeteewoottacharn K,Pairojkul C,Kariya R,Muisuk K,Imtawil K,Chamgramol Y,Bhudhisawasdi V,Khuntikeo N,Pugkhem A,Saeseow OT,Silsirivanit A,Wongkham C,Wongkham S,Okada S

更新日期：2019-05-23 00:00:00

abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

journal_title：Cells

authors： Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

更新日期：2020-02-04 00:00:00

abstract：:The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aqu...

journal_title：Cells

authors： de Mello Santos T,Cavariani MM,Pereira DN,Schimming BC,Chuffa LGA,Domeniconi RF

更新日期：2019-09-17 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...

journal_title：Cells

authors： Syed SN,Raue R,Weigert A,von Knethen A,Brüne B

更新日期：2019-07-28 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

journal_title：Cells

authors： Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

更新日期：2020-05-08 00:00:00

abstract：:Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis. We previously observed that dose levels of SFN are crucial in determining life or death of l...

journal_title：Cells

authors： Chhunchha B,Kubo E,Singh DP

更新日期：2019-09-27 00:00:00

abstract：:With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Dis...

journal_title：Cells

authors： Carion TW,Ebrahim AS,Kracht D,Agrawal A,Strand E,Kaddurah O,McWhirter CR,Sosne G,Berger EA

更新日期：2018-09-20 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

journal_title：Cells

authors： White S,Lin L,Hu K

更新日期：2020-05-29 00:00:00