Abstract：
:Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm each time a cell divides, due to breakdown of the nuclear membrane at entry into mitosis and subsequent nuclear exclusion of nuclear material at exit from mitosis. Here we review the biochemical and biophysical transitions that occur in PML bodies during mitosis and discuss this in light of post-mitotic nuclear import, cell fate decision and acute promyelocytic leukemia therapy.
journal_name
Cellsjournal_title
Cellsauthors
Lång A,Lång E,Bøe SOdoi
10.3390/cells8080893subject
Has Abstractpub_date
2019-08-14 00:00:00issue
8issn
2073-4409pii
cells8080893journal_volume
8pub_type
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