Multiple Export Mechanisms for mRNAs.

abstract：:The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

journal_title：Cells

authors： White S,Lin L,Hu K

更新日期：2020-05-29 00:00:00

abstract：:A new epoch is emerging with intense research on nutraceuticals, i.e., "food or food product that provides medical or health benefits including the prevention and treatment of diseases", such as Alzheimer's disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuropro...

journal_title：Cells

authors： Atlante A,Amadoro G,Bobba A,Latina V

更新日期：2020-10-23 00:00:00

abstract：:Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...

journal_title：Cells

authors： Fritzen AM,Thøgersen FB,Thybo K,Vissing CR,Krag TO,Ruiz-Ruiz C,Risom L,Wibrand F,Høeg LD,Kiens B,Duno M,Vissing J,Jeppesen TD

更新日期：2019-03-12 00:00:00

abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...

journal_title：Cells

authors： Fantini V,Bordoni M,Scocozza F,Conti M,Scarian E,Carelli S,Di Giulio AM,Marconi S,Pansarasa O,Auricchio F,Cereda C

更新日期：2019-08-05 00:00:00

abstract：:Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivator...

journal_title：Cells

authors： Mittermeier C,Konopa A,Muehlich S

更新日期：2020-11-25 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...

journal_title：Cells

authors： Nouwen LV,Everts B

更新日期：2020-01-09 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...

journal_title：Cells

authors： Erkilic N,Gatinois V,Torriano S,Bouret P,Sanjurjo-Soriano C,Luca V,Damodar K,Cereso N,Puechberty J,Sanchez-Alcudia R,Hamel CP,Ayuso C,Meunier I,Pellestor F,Kalatzis V

更新日期：2019-09-11 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...

journal_title：Cells

authors： Hu M,Bogoyevitch MA,Jans DA

更新日期：2019-11-11 00:00:00

abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...

journal_title：Cells

authors： Laferrière F,He X,Zinghirino F,Doudnikoff E,Faggiani E,Meissner WG,Bezard E,De Giorgi F,Ichas F

更新日期：2020-10-29 00:00:00

abstract：:One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research...

journal_title：Cells

authors： Hasanovic A,Mus-Veteau I

更新日期：2018-08-14 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstr...

journal_title：Cells

authors： Sarowar T,Grabrucker AM

更新日期：2020-08-26 00:00:00

abstract：:Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...

journal_title：Cells

authors： Huang Y,Yi X,Kang C,Wu C

更新日期：2019-10-16 00:00:00

abstract：:Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA have not been elucidated. In the present work, we evaluated the effects and the mechanisms of IL-26 on M1 and M2 macrophage differentiation. Hu...

journal_title：Cells

authors： Lin YH,Wang YH,Peng YJ,Liu FC,Lin GJ,Huang SH,Sytwu HK,Cheng CP

更新日期：2020-04-10 00:00:00

abstract：:Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In t...

journal_title：Cells

authors： Taguchi YH,Wang H

更新日期：2018-12-05 00:00:00

abstract：:Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...

journal_title：Cells

authors： Whitaker RH,Placzek WJ

更新日期：2019-04-12 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...

journal_title：Cells

authors： Ichise Y,Saegusa J,Tanaka-Natsui S,Naka I,Hayashi S,Kuroda R,Morinobu A

更新日期：2020-07-14 00:00:00

abstract：:The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a...

journal_title：Cells

authors： Adu-Agyeiwaah Y,Grant MB,Obukhov AG

更新日期：2020-11-23 00:00:00

abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...

journal_title：Cells

authors： Marchetti AL,Guo H

更新日期：2020-11-06 00:00:00

abstract：:Myelination of neuronal axons is essential for proper brain functioning and requires mature myelinating oligodendrocytes (myOLs). The human OL cell lines HOG and MO3.13 have been widely used as in vitro models to study OL (dys) functioning. Here we applied a number of protocols aimed at differentiating HOG and MO3.13 ...

journal_title：Cells

authors： De Kleijn KMA,Zuure WA,Peijnenborg J,Heuvelmans JM,Martens GJM

更新日期：2019-09-17 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...

journal_title：Cells

authors： Gragnani L,Lorini S,Marri S,Zignego AL

更新日期：2020-12-24 00:00:00

abstract：:Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...

journal_title：Cells

authors： Rodríguez C,Martínez-González J

更新日期：2019-11-21 00:00:00

abstract：:Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...

journal_title：Cells

authors： Amir M,Khan P,Queen A,Dohare R,Alajmi MF,Hussain A,Islam A,Ahmad F,Hassan I

更新日期：2020-02-04 00:00:00

abstract：:The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic ...

journal_title：Cells

authors： Hayden MR

更新日期：2020-11-13 00:00:00

abstract：:With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Dis...

journal_title：Cells

authors： Carion TW,Ebrahim AS,Kracht D,Agrawal A,Strand E,Kaddurah O,McWhirter CR,Sosne G,Berger EA

更新日期：2018-09-20 00:00:00

abstract：:The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions thro...

journal_title：Cells

authors： Gundogdu R,Hergovich A

更新日期：2019-06-10 00:00:00

abstract：:Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes ...

journal_title：Cells

authors： Happé C,Kurakula K,Sun XQ,da Silva Goncalves Bos D,Rol N,Guignabert C,Tu L,Schalij I,Wiesmeijer KC,Tura-Ceide O,Vonk Noordegraaf A,de Man FS,Bogaard HJ,Goumans MJ

更新日期：2020-06-08 00:00:00