Abstract：
:A new epoch is emerging with intense research on nutraceuticals, i.e., "food or food product that provides medical or health benefits including the prevention and treatment of diseases", such as Alzheimer's disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence the composition of the intestinal microbiota significantly contributing to the discovery that differential microorganisms composition is associated with the formation and aggregation of cerebral toxic proteins. Further, the routes of interaction between epigenetic mechanisms and the microbiota-gut-brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. This review examines recent scientific literature addressing the beneficial effects of some natural products for which mechanistic evidence to prevent or slowdown AD are available. Even if the road is still long, the results are already exceptional.
journal_name
Cellsjournal_title
Cellsauthors
Atlante A,Amadoro G,Bobba A,Latina Vdoi
10.3390/cells9112347subject
Has Abstractpub_date
2020-10-23 00:00:00issue
11issn
2073-4409pii
cells9112347journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010070
更新日期：2019-12-27 00:00:00
abstract：:The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been c...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8020153
更新日期：2019-02-12 00:00:00
abstract：:Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010144
更新日期：2021-01-12 00:00:00
abstract：:EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112505
更新日期：2020-11-19 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051174
更新日期：2020-05-08 00:00:00
abstract：:Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivator...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122540
更新日期：2020-11-25 00:00:00
abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100173
更新日期：2018-10-17 00:00:00
abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050504
更新日期：2019-05-24 00:00:00
abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8020158
更新日期：2019-02-14 00:00:00
abstract：:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040929
更新日期：2020-04-10 00:00:00
abstract：:For years, moderate hypothermia (32 °C) has been proposed as an unorthodox therapy for liver injuries, with proven hepatoprotective potential. Yet, limited mechanistic understanding has largely denied its acceptance over conventional pharmaceuticals for hepatoprotection. Today, facing a high prevalence of acetaminophe...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112354
更新日期：2020-10-26 00:00:00
abstract：:Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030659
更新日期：2020-03-09 00:00:00
abstract：:As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops. However, antibodies and their derivatives remain the gold standard for the design of new therapeutics. In response, clinical-stage therapeutic proteins ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030610
更新日期：2020-03-04 00:00:00
abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells5020016
更新日期：2016-04-06 00:00:00
abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8090984
更新日期：2019-08-27 00:00:00
abstract：:Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll-/-) exhibit elevated tissue levels of MAGs in association with res...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122705
更新日期：2020-12-17 00:00:00
abstract：:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120271
更新日期：2018-12-13 00:00:00
abstract：:Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interes...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8070754
更新日期：2019-07-20 00:00:00
abstract：:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have histor...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040974
更新日期：2020-04-15 00:00:00
abstract：:Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor cells with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition and stemness potential, and this heterogeneity can hinder their characteriza...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010158
更新日期：2021-01-15 00:00:00
abstract：:Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010101
更新日期：2021-01-08 00:00:00
abstract：:Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human BPIFB4 gene protects cardiac function in the ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051283
更新日期：2020-05-21 00:00:00
abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020486
更新日期：2020-02-20 00:00:00
abstract：:The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleuki...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051311
更新日期：2020-05-25 00:00:00
abstract：:Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8070669
更新日期：2019-07-02 00:00:00
abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040953
更新日期：2020-04-13 00:00:00
abstract：:Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells10020244
更新日期：2021-01-27 00:00:00
abstract：:A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-associated glucocort...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051068
更新日期：2020-04-25 00:00:00
abstract：:In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010102
更新日期：2019-12-31 00:00:00
abstract：:Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010052
更新日期：2020-12-31 00:00:00
