Abstract：
:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regulating inflammatory responses. During the past two decades, accumulated evidence has revealed the intrinsic connection between autophagy and macrophage function. This review focuses on the role of autophagy, both as nonselective and selective forms, in the regulation of the inflammatory and phagocytotic functions of macrophages. Specifically, the roles of autophagy in pattern recognition, cytokine release, inflammasome activation, macrophage polarization, LC3-associated phagocytosis, and xenophagy are comprehensively reviewed. The roles of autophagy receptors in the macrophage function regulation are also summarized. Finally, the obstacles and remaining questions regarding the molecular regulation mechanisms, disease association, and therapeutic applications are discussed.
journal_name
Cellsjournal_title
Cellsauthors
Wu MY,Lu JHdoi
10.3390/cells9010070subject
Has Abstractpub_date
2019-12-27 00:00:00issue
1issn
2073-4409pii
cells9010070journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040977
更新日期：2020-04-15 00:00:00
abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121627
更新日期：2019-12-12 00:00:00
abstract：:Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110221
更新日期：2018-11-21 00:00:00
abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122584
更新日期：2020-12-02 00:00:00
abstract：:Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081793
更新日期：2020-07-28 00:00:00
abstract：:Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111396
更新日期：2019-11-06 00:00:00
abstract：:Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell signaling, both in healthy and pathologic conditions. Being nano-size...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122569
更新日期：2020-12-01 00:00:00
abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030709
更新日期：2020-03-13 00:00:00
abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells5020028
更新日期：2016-06-14 00:00:00
abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051076
更新日期：2020-04-26 00:00:00
abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071585
更新日期：2020-06-30 00:00:00
abstract：:Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030740
更新日期：2020-03-17 00:00:00
abstract：:P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101286
更新日期：2019-10-21 00:00:00
abstract：:Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1-4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly rea...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121483
更新日期：2019-11-21 00:00:00
abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010072
更新日期：2019-12-27 00:00:00
abstract：:Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050415
更新日期：2019-05-05 00:00:00
abstract：:β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac fu...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010154
更新日期：2021-01-14 00:00:00
abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020334
更新日期：2020-02-01 00:00:00
abstract：:Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction. The fact that INSR and IGF1R can function as transcription factors, capable of ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121499
更新日期：2019-11-23 00:00:00
abstract：:Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010056
更新日期：2021-01-01 00:00:00
abstract：:Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8040346
更新日期：2019-04-12 00:00:00
abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081811
更新日期：2020-07-30 00:00:00
abstract：:Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051314
更新日期：2020-05-25 00:00:00
abstract：:Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092131
更新日期：2020-09-20 00:00:00
abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040870
更新日期：2020-04-02 00:00:00
abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100173
更新日期：2018-10-17 00:00:00
abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1041010
更新日期：2012-11-05 00:00:00
abstract：:The methylation of histone H3 at lysine 79 is a feature of open chromatin. It is deposited by the conserved histone methyltransferase DOT1. Recently, DOT1 localization and H3K79 methylation (H3K79me) have been correlated with enhancers in C. elegans and mammalian cells. Since earlier research implicated H3K79me in pre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081846
更新日期：2020-08-06 00:00:00
abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020390
更新日期：2020-02-07 00:00:00
abstract：:Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030659
更新日期：2020-03-09 00:00:00
