Abstract：
:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity.
journal_name
Cellsjournal_title
Cellsauthors
Laronha H,Caldeira Jdoi
10.3390/cells9051076subject
Has Abstractpub_date
2020-04-26 00:00:00issue
5issn
2073-4409pii
cells9051076journal_volume
9pub_type
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