Abstract：
:Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.
journal_name
Cellsjournal_title
Cellsauthors
Gonzalez-Molina J,Gramolelli S,Liao Z,Carlson JW,Ojala PM,Lehti Kdoi
10.3390/cells8090991subject
Has Abstractpub_date
2019-08-28 00:00:00issue
9issn
2073-4409pii
cells8090991journal_volume
8pub_type
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