NF-κB and tPA Signaling in Kidney and Other Diseases.

abstract：:Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...

journal_title：Cells

authors： Damanti CC,Gaffo E,Lovisa F,Garbin A,Di Battista P,Gallingani I,Tosato A,Pillon M,Carraro E,Mascarin M,Elia C,Biffi A,Bortoluzzi S,Mussolin L

更新日期：2021-01-08 00:00:00

abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...

journal_title：Cells

authors： Fossati G,Matteoli M,Menna E

更新日期：2020-09-26 00:00:00

abstract：:The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...

journal_title：Cells

authors： Blackwood EA,Bilal AS,Stauffer WT,Arrieta A,Glembotski CC

更新日期：2020-03-03 00:00:00

abstract：:Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...

journal_title：Cells

authors： Messner M,Ghadge SK,Maurer T,Graber M,Staggl S,Christine Maier S,Pölzl G,Zaruba MM

更新日期：2020-08-28 00:00:00

abstract：:DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprin...

journal_title：Cells

authors： Borchiellini M,Ummarino S,Di Ruscio A

更新日期：2019-10-12 00:00:00

abstract：:The Rho GTPases comprise a subfamily of the Ras superfamily of small GTPases. Their importance in regulation of cell morphology and cell migration is well characterized. According to the prevailing paradigm, Cdc42 regulates the formation of filopodia, Rac1 regulates the formation of lamellipodia, and RhoA triggers the...

journal_title：Cells

authors： Aspenström P

更新日期：2019-07-21 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis. We report here on its involvement in cellular reprogramming from fibroblasts to induced pluripotent stem cells, ...

journal_title：Cells

authors： Divvela SSK,Nell P,Napirei M,Zaehres H,Chen J,Gerding WM,Nguyen HP,Gao S,Brand-Saberi B

更新日期：2019-06-02 00:00:00

abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...

journal_title：Cells

authors： Song W,Wang F,Chen L,Ma R,Zuo X,Cao A,Xie S,Chen X,Jin X,Li H

更新日期：2019-09-05 00:00:00

abstract：:Skin models with efficient skin barrier function are required for percutaneous absorption studies. The contribution of media supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) to the development of the skin barrier function of in vitro skin models remains incompletely understood. To investigate wheth...

journal_title：Cells

authors： Simard M,Julien P,Fradette J,Pouliot R

更新日期：2019-09-25 00:00:00

abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

journal_title：Cells

authors： Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

更新日期：2020-07-15 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...

journal_title：Cells

authors： Hu M,Bogoyevitch MA,Jans DA

更新日期：2019-11-11 00:00:00

abstract：:The present Special Issue on "Cells in Cardiovascular Disease" wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory system [...]. ...

journal_title：Cells

authors： Martínez-González J,García de Frutos P

更新日期：2020-09-29 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...

journal_title：Cells

authors： Akil AA,Jerman LF,Yassin E,Padmajeya SS,Al-Kurbi A,Fakhro KA

更新日期：2020-11-03 00:00:00

abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...

journal_title：Cells

authors： Kristiani L,Kim M,Kim Y

更新日期：2020-03-14 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...

journal_title：Cells

authors： Syed SN,Raue R,Weigert A,von Knethen A,Brüne B

更新日期：2019-07-28 00:00:00

abstract：:The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their ro...

journal_title：Cells

authors： Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini A

更新日期：2014-08-05 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and clinical safety. We characterized the variable osteogenic capacity observed between different human pluripotent stem cell lines. By focusing on the miRNA expression pr...

journal_title：Cells

authors： Barrault L,Gide J,Qing T,Lesueur L,Tost J,Denis JA,Cailleret M,Aubry L,Peschanski M,Martinat C,Baghdoyan S

更新日期：2019-11-26 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...

journal_title：Cells

authors： Kolb K,Hellinger J,Kansy M,Wegwitz F,Bauerschmitz G,Emons G,Gründker C

更新日期：2020-12-05 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic intracellular microbes. Autophagy is a dynamic process in which the diffe...

journal_title：Cells

authors： Domínguez-Martín E,Cardenal-Muñoz E,King JS,Soldati T,Coria R,Escalante R

更新日期：2017-07-03 00:00:00

abstract：:HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our ce...

journal_title：Cells

authors： Bonam SR,Ruff M,Muller S

更新日期：2019-08-07 00:00:00

abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...

journal_title：Cells

authors： Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

更新日期：2020-04-04 00:00:00

abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...

journal_title：Cells

authors： Mondello S,Guedes VA,Lai C,Czeiter E,Amrein K,Kobeissy F,Mechref Y,Jeromin A,Mithani S,Martin C,Wagner CL,Czigler A,Tóth L,Fazekas B,Buki A,Gill J

更新日期：2020-04-15 00:00:00

abstract：:Pharmaco-therapeutic strategies of atrial fibrillation (AF) are moderately effective and do not prevent AF onset and progression. Therefore, there is an urgent need to develop novel therapies. Previous studies revealed heat shock protein (HSP)-inducing compounds to mitigate AF onset and progression. Such an HSP induci...

journal_title：Cells

authors： Starreveld R,Ramos KS,Muskens AJQM,Brundel BJJM,de Groot NMS

更新日期：2020-07-20 00:00:00