Abstract：
:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity.
journal_name
Cellsjournal_title
Cellsauthors
Fossati G,Matteoli M,Menna Edoi
10.3390/cells9102173subject
Has Abstractpub_date
2020-09-26 00:00:00issue
10issn
2073-4409pii
cells9102173journal_volume
9pub_type
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