Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses.

abstract：:Leucine Rich Repeat of Flightless-1 Interacting Protein 1/GC-binding factor 2 (LRRFIP1/GCF2) cDNA was cloned for a transcriptional repressor GCF2, which bound sequence-specifically to a GC-rich element of epidermal growth factor receptor (EGFR) gene and repressed its promotor. LRRFIP1/GCF2 was also cloned as a double ...

journal_title：Cells

authors： Takimoto M

更新日期：2019-01-31 00:00:00

abstract：:Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...

journal_title：Cells

authors： Kim W,Lee S,Seo D,Kim D,Kim K,Kim E,Kang J,Seong KM,Youn H,Youn B

更新日期：2019-09-18 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...

journal_title：Cells

authors： Nally FK,De Santi C,McCoy CE

更新日期：2019-06-05 00:00:00

abstract：:Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...

journal_title：Cells

authors： Fernandes J,Miranda RL,de Lemos ERS,Guterres A

更新日期：2020-11-23 00:00:00

abstract：:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...

journal_title：Cells

authors： Aguilera MO,Delgui LR,Romano PS,Colombo MI

更新日期：2018-10-10 00:00:00

abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...

journal_title：Cells

authors： Smialek MJ,Ilaslan E,Sajek MP,Swiercz A,Janecki DM,Kusz-Zamelczyk K,Wozniak T,Kotecki M,Handschuh L,Figlerowicz M,Jaruzelska J

更新日期：2020-04-16 00:00:00

abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...

journal_title：Cells

authors： Huaman J,Naidoo M,Zang X,Ogunwobi OO

更新日期：2019-06-20 00:00:00

abstract：:The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...

journal_title：Cells

authors： Blackwood EA,Bilal AS,Stauffer WT,Arrieta A,Glembotski CC

更新日期：2020-03-03 00:00:00

abstract：:Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...

journal_title：Cells

authors： Okamoto T,Kawamoto E,Usuda H,Tanaka T,Nikai T,Asanuma K,Suzuki K,Shimaoka M,Wada K

更新日期：2020-07-30 00:00:00

abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...

journal_title：Cells

authors： Laferrière F,He X,Zinghirino F,Doudnikoff E,Faggiani E,Meissner WG,Bezard E,De Giorgi F,Ichas F

更新日期：2020-10-29 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...

journal_title：Cells

authors： Cheng X,Li L,Shi G,Chen L,Fang C,Li M,Li C

更新日期：2020-02-15 00:00:00

abstract：:The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...

journal_title：Cells

authors： Stochaj U,Weber SC

更新日期：2020-02-25 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

journal_title：Cells

authors： Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

更新日期：2020-08-18 00:00:00

abstract：:Nicotinamide (NAM), the amide form of vitamin B3, plays pivotal roles in regulating various cellular processes including energy production and maintenance of genomic stability. The current study aimed at deciphering the effect of NAM, when administered during in vitro maturation (IVM), on the developmental competence ...

journal_title：Cells

authors： El Sheikh M,Mesalam AA,Idrees M,Sidrat T,Mesalam A,Lee KL,Kong IK

更新日期：2020-06-25 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1-5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its vasoconstrictor effects. We aimed to separate the beneficial and potentially de...

journal_title：Cells

authors： Wafa D,Koch N,Kovács J,Kerék M,Proia RL,Tigyi GJ,Benyó Z,Miklós Z

更新日期：2020-07-24 00:00:00

abstract：:Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a transition from rather homogeneous epithelial-like pluripotent stem cell colonies into a three-dimensional organization of various cell types w...

journal_title：Cells

authors： Zeevaert K,Elsafi Mabrouk MH,Wagner W,Goetzke R

更新日期：2020-10-11 00:00:00

abstract：:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structura...

journal_title：Cells

authors： Mikhaylova M,Rentsch J,Ewers H

更新日期：2020-09-01 00:00:00

abstract：:Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...

journal_title：Cells

authors： Wang Q,Zhu Y,Zou X,Li F,Zhang J,Kang Z,Li X,Yin C,Lin Y

更新日期：2020-04-09 00:00:00

abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...

journal_title：Cells

authors： Guo ZH,Yi HC,You ZH

更新日期：2019-08-09 00:00:00

abstract：:The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...

journal_title：Cells

authors： Shukla E,Chauhan R

更新日期：2019-09-27 00:00:00

abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...

journal_title：Cells

authors： Sehadova H,Takasu Y,Zaloudikova A,Lin YH,Sauman I,Sezutsu H,Rouhova L,Kodrik D,Zurovec M

更新日期：2020-12-11 00:00:00

abstract：:Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes. These include the nuclear envelope assembly and stability, mechanotransduction and chromatin organization, transcription, DNA replication, damage repair, and genomic in...

journal_title：Cells

authors： Blank M

更新日期：2020-05-27 00:00:00

abstract：:In 2011, I was invited to serve as the Editor-In-Chief for Cells, which back then was a "new kid on the block" among open access (OA) journals.[...]. ...

journal_title：Cells

authors： Kalyuzhny AE

更新日期：2017-11-01 00:00:00

abstract：:The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...

journal_title：Cells

authors： Dobner J,Simons IM,Rufinatscha K,Hänsch S,Schwarten M,Weiergräber OH,Abdollahzadeh I,Gensch T,Bode JG,Hoffmann S,Willbold D

更新日期：2020-05-22 00:00:00

abstract：:Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWA...

journal_title：Cells

authors： Golov AK,Kondratyev NV,Kostyuk GP,Golimbet AVE

更新日期：2020-01-18 00:00:00

abstract：:Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a, TAC5-c, ...

journal_title：Cells

authors： Patra MC,Achek A,Kim GY,Panneerselvam S,Shin HJ,Baek WY,Lee WH,Sung J,Jeong U,Cho EY,Kim W,Kim E,Suh CH,Choi S

更新日期：2020-07-09 00:00:00