Abstract:
:The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 and mTORC2. mTORC1 coordinates cell growth and metabolism in response to environmental input, including growth factors, amino acid, energy and stress. mTORC2 mainly controls cell survival and migration through phosphorylating glucocorticoid-regulated kinase (SGK), protein kinase B (Akt), and protein kinase C (PKC) kinase families. The dysregulation of mTOR is involved in human diseases including cancer, cardiovascular diseases, neurodegenerative diseases, and epilepsy. Tissue damage caused by trauma, diseases or aging disrupt the tissue functions. Tissue regeneration after injuries is of significance for recovering the tissue homeostasis and functions. Mammals have very limited regenerative capacity in multiple tissues and organs, such as the heart and central nervous system (CNS). Thereby, understanding the mechanisms underlying tissue regeneration is crucial for tissue repair and regenerative medicine. mTOR is activated in multiple tissue injuries. In this review, we summarize the roles of mTOR signaling in tissue regeneration such as neurons, muscles, the liver and the intestine.
journal_name
Cellsjournal_title
Cellsauthors
Wei X,Luo L,Chen Jdoi
10.3390/cells8091075subject
Has Abstractpub_date
2019-09-12 00:00:00issue
9issn
2073-4409pii
cells8091075journal_volume
8pub_type
杂志文章,评审相关文献
Cells文献大全abstract::Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010052
更新日期:2020-12-31 00:00:00
abstract::Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells4030452
更新日期:2015-08-28 00:00:00
abstract::Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060618
更新日期:2019-06-20 00:00:00
abstract::Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030784
更新日期:2020-03-24 00:00:00
abstract::(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030709
更新日期:2020-03-13 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:Cells
pub_type: 已发布勘误
doi:10.3390/cells9102165
更新日期:2020-09-24 00:00:00
abstract::Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080893
更新日期:2019-08-14 00:00:00
abstract::The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121543
更新日期:2019-11-29 00:00:00
abstract::A new epoch is emerging with intense research on nutraceuticals, i.e., "food or food product that provides medical or health benefits including the prevention and treatment of diseases", such as Alzheimer's disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuropro...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112347
更新日期:2020-10-23 00:00:00
abstract::Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091981
更新日期:2020-08-28 00:00:00
abstract::The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn, hypoxic conditions. Hypoxia has been associated with poor clinical out...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040992
更新日期:2020-04-16 00:00:00
abstract::Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030740
更新日期:2020-03-17 00:00:00
abstract::Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8090993
更新日期:2019-08-28 00:00:00
abstract::Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102284
更新日期:2020-10-13 00:00:00
abstract::Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102204
更新日期:2020-09-29 00:00:00
abstract::The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the step...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020271
更新日期:2020-01-22 00:00:00
abstract::Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of t...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051189
更新日期:2020-05-11 00:00:00
abstract::During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020378
更新日期:2020-02-06 00:00:00
abstract::Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051211
更新日期:2020-05-13 00:00:00
abstract::Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030727
更新日期:2020-03-16 00:00:00
abstract::Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7100171
更新日期:2018-10-15 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091068
更新日期:2019-09-11 00:00:00
abstract::Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of pathology, and a spectrum of experimental models have been developed towa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071713
更新日期:2020-07-16 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030704
更新日期:2020-03-13 00:00:00
abstract::Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081837
更新日期:2020-08-05 00:00:00
abstract::Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030592
更新日期:2020-03-02 00:00:00
abstract::Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells3020288
更新日期:2014-04-09 00:00:00
abstract::Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102312
更新日期:2020-10-17 00:00:00
abstract::Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8040346
更新日期:2019-04-12 00:00:00
abstract::In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there has been a great deal of progress in the implementation of EpCAM-based CTC detection technol...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081836
更新日期:2020-08-05 00:00:00