Abstract:
:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be considered as a potential therapeutic agent for cancer treatment. The purpose of this study was to assess the AMHRII expression in endometrial cancer (EC) in correlation to various demographic data and clinical conditions. Immunohistochemical analysis was used to assess AMHRII expression in EC tissue samples retrieved from 230 women with pre-cancerous state of endometrium (PCS) and EC. AMHRII was detected in 100% of samples. No statistical difference was observed for AMHRII expression depending on the histopathological type of EC, cancer staging, body mass index, and age, as well as the number of years of menstruation, births and miscarriages, and average and total breastfeeding time. Diabetes mellitus type 2 is the only factor that has an impact on AMHRII expression in EC tissue. Thus, this study supports the idea of theoretical use of AMH in EC treatment because all histopathological types of EC at all stages of advancement present receptors for AMH.
journal_name
Cellsjournal_title
Cellsauthors
Gowkielewicz M,Lipka A,Majewska M,Piotrowska A,Szadurska-Noga M,Nowakowski JJ,Wiszpolska M,Dzięgiel P,Wasniewski T,Majewski MK,Jozwik Mdoi
10.3390/cells9102312subject
Has Abstractpub_date
2020-10-17 00:00:00issue
10issn
2073-4409pii
cells9102312journal_volume
9pub_type
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