Abstract:
:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-established mouse model of RA. Arthritis was induced in BALB/c and ZAP-70+/- heterozygous mice. Disease progression was monitored using a scoring system and in vivo imaging, antigen-specific proliferation, cytokine and autoantibody production was measured and T cell apoptotic pathways were analyzed. ZAP-70+/- mice developed a less severe arthritis, as shown by both clinical picture and in vitro parameters (decreased T cell proliferation, cytokine and autoantibody production). The amount of cleaved Caspase-3 increased in arthritic ZAP-70+/- T cells, with no significant changes in cleaved Caspase-8 and -9 levels; although expression of Bim, Bcl-2 and Cytochrome C showed alterations. Tyrosine phosphorylation was less pronounced in arthritic ZAP-70+/- T cells and the amount of Cbl-b-a negative regulator of T cell activation-decreased as well. We hypothesize that the less severe disease seen in the partial absence of ZAP-70 might be caused by the decreased T cell activation accompanied by increased apoptosis.
journal_name
Cellsjournal_title
Cellsauthors
Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár Fdoi
10.3390/cells8050504subject
Has Abstractpub_date
2019-05-24 00:00:00issue
5issn
2073-4409pii
cells8050504journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030704
更新日期:2020-03-13 00:00:00
abstract::Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes and cardiovascular disease, and greatly acceler...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8111336
更新日期:2019-10-29 00:00:00
abstract::Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102213
更新日期:2020-09-29 00:00:00
abstract::Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8091105
更新日期:2019-09-18 00:00:00
abstract::Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR rela...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7110185
更新日期:2018-10-25 00:00:00
abstract::Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8030215
更新日期:2019-03-04 00:00:00
abstract::Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction. The fact that INSR and IGF1R can function as transcription factors, capable of ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121499
更新日期:2019-11-23 00:00:00
abstract::BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030574
更新日期:2020-02-28 00:00:00
abstract::HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010192
更新日期:2021-01-19 00:00:00
abstract::Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by active calcification of the leaflets of the aortic valve. How innate immune cells are involved in disease pathogenesis is not clear. In this study we investigate the role of the pattern recognition receptor Toll-like receptor 7 (TLR...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071710
更新日期:2020-07-16 00:00:00
abstract::Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111396
更新日期:2019-11-06 00:00:00
abstract::Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromati...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7020011
更新日期:2018-02-06 00:00:00
abstract::Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111434
更新日期:2019-11-13 00:00:00
abstract::Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112473
更新日期:2020-11-13 00:00:00
abstract::Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010221
更新日期:2020-01-15 00:00:00
abstract::Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation, adhesion, morphology, exocytosis, and gene expression. As a result,...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111425
更新日期:2019-11-12 00:00:00
abstract::Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a transition from rather homogeneous epithelial-like pluripotent stem cell colonies into a three-dimensional organization of various cell types w...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102270
更新日期:2020-10-11 00:00:00
abstract::Intestinal dysbiosis has recently become known as an important driver of gastrointestinal and liver disease. It remains poorly understood, however, how gastrointestinal microbes bypass the intestinal mucosa and enter systemic circulation to enact an inflammatory immune response. In the context of chronic liver disease...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8111324
更新日期:2019-10-27 00:00:00
abstract::While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030537
更新日期:2020-02-26 00:00:00
abstract::Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102204
更新日期:2020-09-29 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122623
更新日期:2020-12-07 00:00:00
abstract::We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071673
更新日期:2020-07-11 00:00:00
abstract::Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8090993
更新日期:2019-08-28 00:00:00
abstract::Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor cells with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition and stemness potential, and this heterogeneity can hinder their characteriza...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010158
更新日期:2021-01-15 00:00:00
abstract::The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080920
更新日期:2019-08-17 00:00:00
abstract::Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091981
更新日期:2020-08-28 00:00:00
abstract::The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071697
更新日期:2020-07-15 00:00:00
abstract::Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040953
更新日期:2020-04-13 00:00:00
abstract::The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive (ER+) breast cancer (BC) patients. The aim of this study was to analyze if the biological aggressiveness, underlined in ER+ BC tumors with higher AR/ER ratio, co...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9041064
更新日期:2020-04-24 00:00:00
abstract::Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051102
更新日期:2020-04-29 00:00:00