Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids.

abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...

journal_title：Cells

authors： Ritter K,Sodenkamp JC,Hölscher A,Behrends J,Hölscher C

更新日期：2020-12-22 00:00:00

abstract：:Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromati...

journal_title：Cells

authors： Lukášová E,Kovařík A,Kozubek S

更新日期：2018-02-06 00:00:00

abstract：:Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol...

journal_title：Cells

authors： Lyu J,Yang EJ,Shim JS

更新日期：2019-04-28 00:00:00

abstract：:Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell typ...

journal_title：Cells

authors： Santos J,Hubert T,Milthorpe BK

更新日期：2020-03-04 00:00:00

abstract：:Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48-72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the li...

journal_title：Cells

authors： Estrella JFGL,Immanuel J,Wiley V,Simmons D

更新日期：2020-10-15 00:00:00

abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...

journal_title：Cells

authors： Mahli A,Seitz T,Freese K,Frank J,Weiskirchen R,Abdel-Tawab M,Behnam D,Hellerbrand C

更新日期：2019-04-17 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...

journal_title：Cells

authors： Osei ET,Booth S,Hackett TL

更新日期：2020-07-15 00:00:00

abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...

journal_title：Cells

authors： Song W,Wang F,Chen L,Ma R,Zuo X,Cao A,Xie S,Chen X,Jin X,Li H

更新日期：2019-09-05 00:00:00

abstract：:Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...

journal_title：Cells

authors： Di Sanzo M,Quaresima B,Biamonte F,Palmieri C,Faniello MC

更新日期：2020-11-28 00:00:00

abstract：:Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

journal_title：Cells

authors： Frey K,Pucker B

更新日期：2020-02-18 00:00:00

abstract：:(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...

journal_title：Cells

authors： Morresi C,Cianfruglia L,Sartini D,Cecati M,Fumarola S,Emanuelli M,Armeni T,Ferretti G,Bacchetti T

更新日期：2019-12-11 00:00:00

abstract：:Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...

journal_title：Cells

authors： Huang Y,Yi X,Kang C,Wu C

更新日期：2019-10-16 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...

journal_title：Cells

authors： Estadella I,Pedrós-Gámez O,Colomer-Molera M,Bosch M,Sorkin A,Felipe A

更新日期：2020-08-04 00:00:00

abstract：:Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. In inflammation, stroke, aging, or infection, microglia have been shown to contribute to brain pathology in both deleterious and beneficial ways, which have been stu...

journal_title：Cells

authors： Augusto-Oliveira M,Arrifano GP,Lopes-Araújo A,Santos-Sacramento L,Takeda PY,Anthony DC,Malva JO,Crespo-Lopez ME

更新日期：2019-10-22 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...

journal_title：Cells

authors： Chu KB,Lee HA,Kang HJ,Moon EK,Quan FS

更新日期：2020-05-25 00:00:00

abstract：:HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our ce...

journal_title：Cells

authors： Bonam SR,Ruff M,Muller S

更新日期：2019-08-07 00:00:00

abstract：:During embryonic development, the heart undergoes complex morphogenesis from a liner tube into the four chambers consisting of ventricles, atria and valves. At the same time, the cardiomyocytes compact into a dense, aligned, and highly vascularized myocardium. The extracellular matrix (ECM) is known to play an importa...

journal_title：Cells

authors： Jallerat Q,Feinberg AW

更新日期：2020-01-24 00:00:00

abstract：:Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...

journal_title：Cells

authors： Hansen JN,Rassmann S,Jikeli JF,Wachten D

更新日期：2018-12-26 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...

journal_title：Cells

authors： Berger S,Gureczny S,Reisinger SN,Horvath O,Pollak DD

更新日期：2019-09-01 00:00:00

abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...

journal_title：Cells

authors： Lapitz A,Arbelaiz A,O'Rourke CJ,Lavin JL,Casta A,Ibarra C,Jimeno JP,Santos-Laso A,Izquierdo-Sanchez L,Krawczyk M,Perugorria MJ,Jimenez-Aguero R,Sanchez-Campos A,Riaño I,Gónzalez E,Lammert F,Marzioni M,Macias RIR,Marin

更新日期：2020-03-14 00:00:00

abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

journal_title：Cells

authors： Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

更新日期：2020-02-06 00:00:00

abstract：:The aim of this study was to analyze the distribution of killer-cell immunoglobulin-like receptor (KIR) genes and their human leucocyte antigen (HLA) ligand combinations in different original ethnic populations in China, and thus, to provide relevant genomic diversity data for the future study of viral infections, aut...

journal_title：Cells

authors： Yao Y,Shi L,Yu J,Liu S,Tao Y,Shi L

更新日期：2019-07-12 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...

journal_title：Cells

authors： Shukla E,Chauhan R

更新日期：2019-09-27 00:00:00

abstract：:The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors targeting ALK rearrangements, but resistance inevitably emerges. Some of the mechanisms of resistance are sensitive to novel ALK inhibitors but af...

journal_title：Cells

authors： Hofman P

更新日期：2021-01-15 00:00:00

abstract：:Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...

journal_title：Cells

authors： Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller A

更新日期：2019-12-15 00:00:00

abstract：:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...

journal_title：Cells

authors： Lafoz E,Ruart M,Anton A,Oncins A,Hernández-Gea V

更新日期：2020-04-10 00:00:00