Abstract：
:Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromatin domains (termed LAD) and simultaneously bind either lamin A/C or lamin B1. One of these proteins is the lamin B receptor (LBR) that binds lamin B1 and tethers heterochromatin to the INM in embryonic and undifferentiated cells. It is replaced by lamin A/C with specific lamin A/C binding proteins at the beginning of cell differentiation and in differentiated cells. Our functional experiments in cancer cell lines show that heterochromatin in cancer cells is tethered to the INM by LBR, which is downregulated together with lamin B1 at the onset of cell transition to senescence. The downregulation of these proteins in senescent cells leads to the detachment of centromeric repetitive sequences from INM, their relocation to the nucleoplasm, and distension. In cells, the expression of LBR and LB1 is highly coordinated as evidenced by the reduction of both proteins in LBR shRNA lines. The loss of the constitutive heterochromatin structure containing LADs results in changes in chromatin architecture and genome function and can be the reason for the permanent loss of cell proliferation in senescence.
journal_name
Cellsjournal_title
Cellsauthors
Lukášová E,Kovařík A,Kozubek Sdoi
10.3390/cells7020011subject
Has Abstractpub_date
2018-02-06 00:00:00issue
2issn
2073-4409pii
cells7020011journal_volume
7pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9092121
更新日期：2020-09-18 00:00:00
abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1010015
更新日期：2012-03-21 00:00:00
abstract：:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyc...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020424
更新日期：2020-02-12 00:00:00
abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111434
更新日期：2019-11-13 00:00:00
abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3041102
更新日期：2014-11-27 00:00:00
abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111445
更新日期：2019-11-15 00:00:00
abstract：:Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8030229
更新日期：2019-03-11 00:00:00
abstract：:Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9041010
更新日期：2020-04-18 00:00:00
abstract：:Cathepsin S (CatS) is a secreted cysteine protease that cleaves certain extracellular matrix proteins, regulates antigen presentation in antigen-presenting cells (APC), and promotes M2-type macrophage and dendritic cell polarization. CatS is overexpressed in many solid cancers, and overall, it appears to promote an im...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092021
更新日期：2020-09-02 00:00:00
abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112430
更新日期：2020-11-06 00:00:00
abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122667
更新日期：2020-12-11 00:00:00
abstract：:There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121605
更新日期：2019-12-11 00:00:00
abstract：:Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040916
更新日期：2020-04-09 00:00:00
abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020348
更新日期：2020-02-03 00:00:00
abstract：:The finding that transcription occurs at chromosome ends has opened new fields of study on the roles of telomeric transcripts in chromosome end maintenance and genome stability. Indeed, the ends of chromosomes are required to be protected from activation of DNA damage response and DNA repair pathways. Chromosome end p...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8030246
更新日期：2019-03-15 00:00:00
abstract：:The endoplasmic reticulum (ER) stress response and autophagy are important cellular responses that determine cell fate and whose dysregulation is implicated in the perturbation of homeostasis and diseases. Tonicity-responsive enhancer-binding protein (TonEBP, also called NFAT5) is a pleiotropic stress protein that med...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091928
更新日期：2020-08-20 00:00:00
abstract：:Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020386
更新日期：2014-05-06 00:00:00
abstract：:Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040805
更新日期：2020-03-26 00:00:00
abstract：:Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8090991
更新日期：2019-08-28 00:00:00
abstract：:The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051296
更新日期：2020-05-22 00:00:00
abstract：:Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases. Here, we show that a novel small molecule TLR-inhibitor (TAC5) and its derivatives TAC5-a, TAC5-c, ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071648
更新日期：2020-07-09 00:00:00
abstract：:Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7100162
更新日期：2018-10-10 00:00:00
abstract：:The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092020
更新日期：2020-09-02 00:00:00
abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010048
更新日期：2020-12-31 00:00:00
abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020390
更新日期：2020-02-07 00:00:00
abstract：:Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081752
更新日期：2020-07-22 00:00:00
abstract：:Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this home...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120224
更新日期：2018-11-22 00:00:00
abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061483
更新日期：2020-06-18 00:00:00
abstract：:Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020359
更新日期：2020-02-04 00:00:00
abstract：:Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...
journal_title：Cells
pub_type： 临床试验,杂志文章
doi：10.3390/cells8030237
更新日期：2019-03-12 00:00:00
