TLR7 Expression Is Associated with M2 Macrophage Subset in Calcific Aortic Valve Stenosis.

abstract：:Microalgae have emerged as a promising platform for production of carbon- and energy- rich molecules, notably starch and oil. Establishing an economically viable algal biotechnology sector requires a holistic understanding of algal photosynthesis, physiology, cell cycle and metabolism. Starch/oil productivity is a com...

journal_title：Cells

authors： Burlacot A,Peltier G,Li-Beisson Y

更新日期：2019-09-26 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...

journal_title：Cells

authors： Tovar I,Guerrero R,López-Peñalver JJ,Expósito J,Ruiz de Almodóvar JM

更新日期：2020-09-02 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...

journal_title：Cells

authors： Gowkielewicz M,Lipka A,Majewska M,Piotrowska A,Szadurska-Noga M,Nowakowski JJ,Wiszpolska M,Dzięgiel P,Wasniewski T,Majewski MK,Jozwik M

更新日期：2020-10-17 00:00:00

abstract：:The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...

journal_title：Cells

authors： Zhang L,Ye Y,Dhar R,Deng J,Tang H

更新日期：2019-10-21 00:00:00

abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

journal_title：Cells

authors： Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

更新日期：2019-06-21 00:00:00

abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...

journal_title：Cells

authors： Samak M,Hinkel R

更新日期：2019-11-27 00:00:00

abstract：:Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...

journal_title：Cells

authors： Celik-Selvi BE,Stütz A,Mayer CE,Salhi J,Siegwart G,Sutterlüty H

更新日期：2019-08-01 00:00:00

abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...

journal_title：Cells

authors： Bécot A,Pardossi-Piquard R,Bourgeois A,Duplan E,Xiao Q,Diwan A,Lee JM,Lauritzen I,Checler F

更新日期：2020-05-12 00:00:00

abstract：:Coronary artery disease is the most common form of cardiovascular diseases, resulting in the loss of cardiomyocytes (CM) at the site of ischemic injury. To compensate for the loss of CMs, cardiac fibroblasts quickly respond to injury and initiate cardiac remodeling in an injured heart. In the remodeling process, cardi...

journal_title：Cells

authors： Bektik E,Fu JD

更新日期：2019-07-04 00:00:00

abstract：:The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro model. To directly assess the ...

journal_title：Cells

authors： Moreno Roig E,Groot AJ,Yaromina A,Hendrickx TC,Barbeau LMO,Giuranno L,Dams G,Ient J,Olivo Pimentel V,van Gisbergen MW,Dubois LJ,Vooijs MA

更新日期：2019-01-12 00:00:00

abstract：:In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the...

journal_title：Cells

authors： Kwon JH,Kim M,Um S,Lee HJ,Bae YK,Choi SJ,Hwang HH,Oh W,Jin HJ

更新日期：2021-01-03 00:00:00

abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...

journal_title：Cells

authors： Carotenuto P,Pecoraro A,Palma G,Russo G,Russo A

更新日期：2019-09-16 00:00:00

abstract：:In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated a...

journal_title：Cells

authors： Schober SJ,Thiede M,Gassmann H,Prexler C,Xue B,Schirmer D,Wohlleber D,Stein S,Grünewald TGP,Busch DH,Richter GHS,Burdach SEG,Thiel U

更新日期：2020-06-29 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...

journal_title：Cells

authors： Kim JY,Barua S,Huang MY,Park J,Yenari MA,Lee JE

更新日期：2020-09-02 00:00:00

abstract：:Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders are the leading causes of death and disability worldwide. Metabolic diseases cause vascular dysfunction and loss of capillaries termed capillary rarefaction. Interestingly, obesity seems to affect capillary beds in an organ-sp...

journal_title：Cells

authors： Paavonsalo S,Hariharan S,Lackman MH,Karaman S

更新日期：2020-12-14 00:00:00

abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...

journal_title：Cells

authors： Gasparini S,Licursi V,Presutti C,Mannironi C

更新日期：2020-07-31 00:00:00

abstract：:Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell's ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial ...

journal_title：Cells

authors： Zhou Z,Austin GL,Young LEA,Johnson LA,Sun R

更新日期：2018-11-23 00:00:00

abstract：:Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed. It is also known to be linked with several aspects of tumor malignancy in some types of human tumors, including invasion, metastasis, and cancer stemness. However, there are few reports on the expression of dog PDPN (dPDPN) in ...

journal_title：Cells

authors： Shinada M,Kato D,Kamoto S,Yoshimoto S,Tsuboi M,Yoshitake R,Eto S,Ikeda N,Saeki K,Hashimoto Y,Takahashi Y,Chambers J,Uchida K,Kaneko MK,Fujita N,Nishimura R,Kato Y,Nakagawa T

更新日期：2020-05-05 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...

journal_title：Cells

authors： Marzano M,Bejoy J,Cheerathodi MR,Sun L,York SB,Zhao J,Kanekiyo T,Bu G,Meckes DG Jr,Li Y

更新日期：2019-08-28 00:00:00

abstract：:Breast cancer-related mortality remains high worldwide, despite tremendous advances in diagnostics and therapeutics; hence, the quest for better strategies for disease management, as well as the identification of modifiable risk factors, continues. With recent leaps in genomic technologies, microbiota have emerged as ...

journal_title：Cells

authors： Parida S,Sharma D

更新日期：2020-04-28 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...

journal_title：Cells

authors： Rigiracciolo DC,Nohata N,Lappano R,Cirillo F,Talia M,Scordamaglia D,Gutkind JS,Maggiolini M

更新日期：2020-04-18 00:00:00

abstract：:The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...

journal_title：Cells

authors： Del Favero G,Mayer RM,Dellafiora L,Janker L,Niederstaetter L,Dall'Asta C,Gerner C,Marko D

更新日期：2020-03-31 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00

abstract：:Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progress...

journal_title：Cells

authors： Valencia J,M Fernández-Sevilla L,Fraile-Ramos A,Sacedón R,Jiménez E,Vicente A,Varas A

更新日期：2019-07-14 00:00:00

abstract：:Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...

journal_title：Cells

authors： Estadella I,Pedrós-Gámez O,Colomer-Molera M,Bosch M,Sorkin A,Felipe A

更新日期：2020-08-04 00:00:00

abstract：:The synucleinopathy underlying multiple system atrophy (MSA) is characterized by the presence of abundant amyloid inclusions containing fibrillar α-synuclein (α-syn) aggregates in the brains of the patients and is associated with an extensive neurodegeneration. In contrast to Parkinson's disease (PD) where the patholo...

journal_title：Cells

authors： Laferrière F,He X,Zinghirino F,Doudnikoff E,Faggiani E,Meissner WG,Bezard E,De Giorgi F,Ichas F

更新日期：2020-10-29 00:00:00

abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...

journal_title：Cells

authors： Kristiani L,Kim M,Kim Y

更新日期：2020-03-14 00:00:00