Abstract：
:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for neuronal proteins and synaptic factors. These features suggested that circRNAs are key components of an important layer of neuronal gene expression regulation, with known and anticipated functions. Here, we review major recognized aspects of circRNA biogenesis, metabolism and biological activities, examining potential new functions in the context of the nervous system.
journal_name
Cellsjournal_title
Cellsauthors
Gasparini S,Licursi V,Presutti C,Mannironi Cdoi
10.3390/cells9081815subject
Has Abstractpub_date
2020-07-31 00:00:00issue
8issn
2073-4409pii
cells9081815journal_volume
9pub_type
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