Molecular Mechanisms Associated with ROR1-Mediated Drug Resistance: Crosstalk with Hippo-YAP/TAZ and BMI-1 Pathways.

abstract：:The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes reportedly share with circular RNAs (circRNAs). Interestingly, some ...

journal_title：Cells

authors： Mfossa ACM,Thekkekara Puthenparampil H,Inalegwu A,Coolkens A,Baatout S,Benotmane MA,Huylebroeck D,Quintens R

更新日期：2019-07-26 00:00:00

abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...

journal_title：Cells

authors： Zhang L,Chen X,Yin J

更新日期：2019-09-06 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

journal_title：Cells

authors： Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

更新日期：2020-05-08 00:00:00

abstract：:Mycobacterium bovis (M. bovis) is a member of the Mycobacterium tuberculosis (Mtb) complex causing bovine tuberculosis (TB) and imposing a high zoonotic threat to human health. Kallikreins (KLKs) belong to a subgroup of secreted serine proteases. As their role is established in various physiological and pathological p...

journal_title：Cells

authors： Sabir N,Hussain T,Liao Y,Wang J,Song Y,Shahid M,Cheng G,Mangi MH,Yao J,Yang L,Zhao D,Zhou X

更新日期：2019-05-05 00:00:00

abstract：:Cannabidiol (CBD), as the only phytocannabinoid that has no psychoactive effect, has both antioxidant and anti-inflammatory effects, and thus might be suggested as a cytoprotective compound against UV-induced metabolic changes in skin cells. Therefore, the aim of this study was to investigate the level of protective C...

journal_title：Cells

authors： Gęgotek A,Atalay S,Domingues P,Skrzydlewska E

更新日期：2019-08-28 00:00:00

abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...

journal_title：Cells

authors： Mondello S,Guedes VA,Lai C,Czeiter E,Amrein K,Kobeissy F,Mechref Y,Jeromin A,Mithani S,Martin C,Wagner CL,Czigler A,Tóth L,Fazekas B,Buki A,Gill J

更新日期：2020-04-15 00:00:00

abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...

journal_title：Cells

authors： Lindner R

更新日期：2017-02-10 00:00:00

abstract：:Myelin sheaths in the central nervous system (CNS) insulate axons and thereby allow saltatory nerve conduction, which is a prerequisite for complex brain function. Multiple sclerosis (MS), the most common inflammatory autoimmune disease of the CNS, leads to the destruction of myelin sheaths and the myelin-producing ol...

journal_title：Cells

authors： Gruchot J,Weyers V,Göttle P,Förster M,Hartung HP,Küry P,Kremer D

更新日期：2019-08-03 00:00:00

abstract：:Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes and cardiovascular disease, and greatly acceler...

journal_title：Cells

authors： Grajales D,Ferreira V,Valverde ÁM

更新日期：2019-10-29 00:00:00

abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...

journal_title：Cells

authors： Marchetti AL,Guo H

更新日期：2020-11-06 00:00:00

abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...

journal_title：Cells

authors： Bonsignori M,Moody MA

更新日期：2012-03-21 00:00:00

abstract：:P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...

journal_title：Cells

authors： Kadioglu O,Efferth T

更新日期：2019-10-21 00:00:00

abstract：:Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...

journal_title：Cells

authors： Oechslin N,Moradpour D,Gouttenoire J

更新日期：2020-05-22 00:00:00

abstract：:Fatty acids are the main respiratory substrates important for cardiac function, and their oxidation is altered during various chronic disorders. We investigated the mechanism of fatty acid-oxidation-induced changes and their relations with mitochondrial morphology and ADP/ATP carrier conformation on the kinetics of th...

journal_title：Cells

authors： Toleikis A,Trumbeckaite S,Liobikas J,Pauziene N,Kursvietiene L,Kopustinskiene DM

更新日期：2020-02-01 00:00:00

abstract：:The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro model. To directly assess the ...

journal_title：Cells

authors： Moreno Roig E,Groot AJ,Yaromina A,Hendrickx TC,Barbeau LMO,Giuranno L,Dams G,Ient J,Olivo Pimentel V,van Gisbergen MW,Dubois LJ,Vooijs MA

更新日期：2019-01-12 00:00:00

abstract：:Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate...

journal_title：Cells

authors： Drechsler Y,Vasconcelos EJR,Griggs LM,Diniz PPPV,Collisson E

更新日期：2020-06-09 00:00:00

abstract：:Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...

journal_title：Cells

authors： Hansen JN,Rassmann S,Jikeli JF,Wachten D

更新日期：2018-12-26 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...

journal_title：Cells

authors： Yong KSM,Her Z,Chen Q

更新日期：2019-06-17 00:00:00

abstract：:CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals. To investigate the function of circ-FoxO3 in mouse myoblast cells' (C2C12) differentiation and proliferation, we used RT-qPCR to detect the expressi...

journal_title：Cells

authors： Li X,Li C,Liu Z,Ni W,Yao R,Xu Y,Quan R,Zhang M,Li H,Liu L,Hu S

更新日期：2019-06-19 00:00:00

abstract：:Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...

journal_title：Cells

authors： Sioud F,Amor S,Toumia IB,Lahmar A,Aires V,Chekir-Ghedira L,Delmas D

更新日期：2020-02-04 00:00:00

abstract：:The Hedgehog pathway (HhP) plays an important role in normal embryonic development and its abnormal function has been linked to a variety of neoplasms. Recently, the complex mechanisms involved in this pathway have been deciphered and the cross talks with other important pathways involved in carcinogenesis have been c...

journal_title：Cells

authors： Girardi D,Barrichello A,Fernandes G,Pereira A

更新日期：2019-02-12 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...

journal_title：Cells

authors： Legartová S,Lochmanová G,Zdráhal Z,Kozubek S,Šponer J,Krepl M,Pokorná P,Bártová E

更新日期：2019-09-17 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in the excitation/inhibition balance (E/I ...

journal_title：Cells

authors： Dooves S,van Velthoven AJH,Suciati LG,Heine VM

更新日期：2021-01-12 00:00:00

abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...

journal_title：Cells

authors： Zheng F,Phelan KD

更新日期：2014-04-09 00:00:00

abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...

journal_title：Cells

authors： Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

更新日期：2019-08-13 00:00:00

abstract：:Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...

journal_title：Cells

authors： Duan TL,He GJ,Hu LD,Yan YB

更新日期：2019-08-05 00:00:00