On the Host Side of the Hepatitis E Virus Life Cycle.

abstract：:Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, ...

journal_title：Cells

authors： Moore G,Annett S,McClements L,Robson T

更新日期：2020-06-20 00:00:00

abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...

journal_title：Cells

authors： Ritter K,Sodenkamp JC,Hölscher A,Behrends J,Hölscher C

更新日期：2020-12-22 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signali...

journal_title：Cells

authors： Ziller N,Kotolloshi R,Esmaeili M,Liebisch M,Mrowka R,Baniahmad A,Liehr T,Wolf G,Loeffler I

更新日期：2020-10-03 00:00:00

abstract：:The co-expression of androgen (AR) and estrogen (ER) receptors, in terms of higher AR/ER ratio, has been recently associated with poor outcome in ER-positive (ER+) breast cancer (BC) patients. The aim of this study was to analyze if the biological aggressiveness, underlined in ER+ BC tumors with higher AR/ER ratio, co...

journal_title：Cells

authors： Rangel N,Rondon-Lagos M,Annaratone L,Aristizábal-Pachon AF,Cassoni P,Sapino A,Castellano I

更新日期：2020-04-24 00:00:00

abstract：:Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...

journal_title：Cells

authors： Sousa L,Pankonien I,Clarke LA,Silva I,Kunzelmann K,Amaral MD

更新日期：2020-07-02 00:00:00

abstract：:HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...

journal_title：Cells

authors： Van Belle S,El Ashkar S,Čermáková K,Matthijssens F,Goossens S,Canella A,Hodges CH,Christ F,De Rijck J,Van Vlierberghe P,Veverka V,Debyser Z

更新日期：2021-01-19 00:00:00

abstract：:Around 2 × 103-2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same functionally capable ubiquitin molecule that all eukaryotic species ...

journal_title：Cells

authors： Zuin A,Isasa M,Crosas B

更新日期：2014-07-10 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...

journal_title：Cells

authors： Laganà M,Schlecht-Louf G,Bachelerie F

更新日期：2021-01-05 00:00:00

abstract：:Fisetin, a natural flavonoid, is known to have anticarcinogenic effects against several cancers, but its role in mediating renal cell carcinoma (RCC) progression has not been delineated. Cell viability, cytotoxicity, and cell cycle distribution were measured using the 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazol...

journal_title：Cells

authors： Hsieh MH,Tsai JP,Yang SF,Chiou HL,Lin CL,Hsieh YH,Chang HR

更新日期：2019-08-21 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the immune system to eradicate malignant tissue. However, it is well recognised that some cancers are highly resistant to these therapies, which is in part attributed to the immunosuppressive landscape of the tumour microenvironment (...

journal_title：Cells

authors： Armitage JD,Newnes HV,McDonnell A,Bosco A,Waithman J

更新日期：2021-01-01 00:00:00

abstract：:Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interes...

journal_title：Cells

authors： Dai Z

更新日期：2019-07-20 00:00:00

abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...

journal_title：Cells

authors： Rinkenbaugh AL,Baldwin AS

更新日期：2016-04-06 00:00:00

abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...

journal_title：Cells

authors： Howe HS,Leung BPL

更新日期：2019-12-27 00:00:00

abstract：:Intestinal dysbiosis has recently become known as an important driver of gastrointestinal and liver disease. It remains poorly understood, however, how gastrointestinal microbes bypass the intestinal mucosa and enter systemic circulation to enact an inflammatory immune response. In the context of chronic liver disease...

journal_title：Cells

authors： Chen D,Le TH,Shahidipour H,Read SA,Ahlenstiel G

更新日期：2019-10-27 00:00:00

abstract：:Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll-/-) exhibit elevated tissue levels of MAGs in association with res...

journal_title：Cells

authors： Dione N,Lacroix S,Taschler U,Deschênes T,Abolghasemi A,Leblanc N,Di Marzo V,Silvestri C

更新日期：2020-12-17 00:00:00

abstract：:Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...

journal_title：Cells

authors： Raasakka A,Kursula P

更新日期：2020-02-18 00:00:00

abstract：:Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol...

journal_title：Cells

authors： Lyu J,Yang EJ,Shim JS

更新日期：2019-04-28 00:00:00

abstract：:Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...

journal_title：Cells

authors： Cammalleri M,Dal Monte M,Amato R,Lapi D,Bagnoli P

更新日期：2020-09-09 00:00:00

abstract：:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...

journal_title：Cells

authors： Minciacchi VR,Kumar R,Krause DS

更新日期：2021-01-10 00:00:00

abstract：:Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration. The present study aimed to define whether MSC conditioned medium could recapitulate the effects of MSC cotransplantation. Mouse bone marro...

journal_title：Cells

authors： Kim YH,Cho KA,Lee HJ,Park M,Shin SJ,Park JW,Woo SY,Ryu KH

更新日期：2020-01-15 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...

journal_title：Cells

authors： Liu Q,Junker A,Murakami K,Hu P

更新日期：2019-09-02 00:00:00

abstract：:Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...

journal_title：Cells

authors： BeLow M,Osipo C

更新日期：2020-09-29 00:00:00

abstract：:Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

journal_title：Cells

authors： Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

更新日期：2020-02-24 00:00:00

abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...

journal_title：Cells

authors： Hu LL,Chang HM,Yi Y,Liu Y,Taylor EL,Zheng LP,Leung PCK

更新日期：2019-11-15 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...

journal_title：Cells

authors： Lee Y,Kim SJ,Choo J,Heo G,Yoo JW,Jung Y,Rhee SH,Im E

更新日期：2020-06-01 00:00:00