Abstract:
:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an increase in intracellular free Ca2+ concentration. Thus, activation of TRPC channels could be a common downstream event of many signaling pathways that contribute to seizure and excitotoxicity, such as N-methyl-D-aspartate (NMDA) receptor-mediated Ca2+ influx, or metabotropic glutamate receptor activation. Recent studies with genetic ablation of various TRPC family members have demonstrated that TRPC channels, in particular heteromeric TRPC1/4 channels and homomeric TRPC5 channels, play a critical role in both pilocarpine-induced acute seizures and neuronal cell death. However, exact underlying mechanisms remain to be fully elucidated, and selective TRPC modulators and antibodies with better specificity are urgently needed for future research.
journal_name
Cellsjournal_title
Cellsauthors
Zheng F,Phelan KDdoi
10.3390/cells3020288subject
Has Abstractpub_date
2014-04-09 00:00:00pages
288-303issue
2issn
2073-4409pii
cells3020288journal_volume
3pub_type
杂志文章相关文献
Cells文献大全abstract::As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122576
更新日期:2020-12-01 00:00:00
abstract::The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7070064
更新日期:2018-06-21 00:00:00
abstract::Coronary artery disease is the most common form of cardiovascular diseases, resulting in the loss of cardiomyocytes (CM) at the site of ischemic injury. To compensate for the loss of CMs, cardiac fibroblasts quickly respond to injury and initiate cardiac remodeling in an injured heart. In the remodeling process, cardi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070679
更新日期:2019-07-04 00:00:00
abstract::Pharmaco-therapeutic strategies of atrial fibrillation (AF) are moderately effective and do not prevent AF onset and progression. Therefore, there is an urgent need to develop novel therapies. Previous studies revealed heat shock protein (HSP)-inducing compounds to mitigate AF onset and progression. Such an HSP induci...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071729
更新日期:2020-07-20 00:00:00
abstract::Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020470
更新日期:2020-02-18 00:00:00
abstract::The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010030
更新日期:2020-12-27 00:00:00
abstract::β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac fu...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010154
更新日期:2021-01-14 00:00:00
abstract::Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010052
更新日期:2020-12-31 00:00:00
abstract::Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070696
更新日期:2019-07-10 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030704
更新日期:2020-03-13 00:00:00
abstract::Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8090991
更新日期:2019-08-28 00:00:00
abstract::Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112525
更新日期:2020-11-23 00:00:00
abstract::The Rho GTPases comprise a subfamily of the Ras superfamily of small GTPases. Their importance in regulation of cell morphology and cell migration is well characterized. According to the prevailing paradigm, Cdc42 regulates the formation of filopodia, Rac1 regulates the formation of lamellipodia, and RhoA triggers the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070759
更新日期:2019-07-21 00:00:00
abstract::The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells1010015
更新日期:2012-03-21 00:00:00
abstract::The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells9030526
更新日期:2020-02-25 00:00:00
abstract::Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030535
更新日期:2020-02-25 00:00:00
abstract::HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080849
更新日期:2019-08-07 00:00:00
abstract::Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8010010
更新日期:2018-12-26 00:00:00
abstract::As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071694
更新日期:2020-07-15 00:00:00
abstract::Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its recepto...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101123
更新日期:2019-09-21 00:00:00
abstract::Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030524
更新日期:2020-02-25 00:00:00
abstract::Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study, the mechanism by which N deficiency influences rice seminal root gr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040916
更新日期:2020-04-09 00:00:00
abstract::The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060059
更新日期:2018-06-14 00:00:00
abstract::Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they fa...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091012
更新日期:2019-08-30 00:00:00
abstract::Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells4030452
更新日期:2015-08-28 00:00:00
abstract::Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010070
更新日期:2019-12-27 00:00:00
abstract::The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated sele...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112416
更新日期:2020-11-04 00:00:00
abstract::The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071585
更新日期:2020-06-30 00:00:00
abstract::Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020508
更新日期:2020-02-24 00:00:00
abstract::Peripheral nerve injuries result in the loss of the motor, sensory and autonomic functions of the denervated segments of the body. Neurons can regenerate after peripheral axotomy, but inaccuracy in reinnervation causes a permanent loss of function that impairs complete recovery. Thus, understanding how regenerating ax...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092131
更新日期:2020-09-20 00:00:00