What Have In Vitro Co-Culture Models Taught Us about the Contribution of Epithelial-Mesenchymal Interactions to Airway Inflammation and Remodeling in Asthma?

abstract：:During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...

journal_title：Cells

authors： Plesner T,van de Donk N,Richardson PG

更新日期：2020-02-06 00:00:00

abstract：:In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...

journal_title：Cells

authors： Avalos-de León CG,Jiménez-Castro MB,Cornide-Petronio ME,Casillas-Ramírez A,Peralta C

更新日期：2019-12-09 00:00:00

abstract：:Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

journal_title：Cells

authors： Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

更新日期：2020-02-03 00:00:00

abstract：:Calcific aortic valve stenosis (CAVS) is a common age-related disease characterized by active calcification of the leaflets of the aortic valve. How innate immune cells are involved in disease pathogenesis is not clear. In this study we investigate the role of the pattern recognition receptor Toll-like receptor 7 (TLR...

journal_title：Cells

authors： Karadimou G,Plunde O,Pawelzik SC,Carracedo M,Eriksson P,Franco-Cereceda A,Paulsson-Berne G,Bäck M

更新日期：2020-07-16 00:00:00

abstract：:Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably by annexins (Anx) is critical for membrane repair. We applied me...

journal_title：Cells

authors： Croissant C,Gounou C,Bouvet F,Tan S,Bouter A

更新日期：2020-07-21 00:00:00

abstract：:The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...

journal_title：Cells

authors： Luteijn RD,Praest P,Thiele F,Sadasivam SM,Singethan K,Drijfhout JW,Bach C,de Boer SM,Lebbink RJ,Tao S,Helfer M,Bach NC,Protzer U,Costa AI,Killian JA,Drexler I,Wiertz EJHJ

更新日期：2020-08-29 00:00:00

abstract：:Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bac...

journal_title：Cells

authors： Zhou X,Yang G,Guan F

更新日期：2020-01-22 00:00:00

abstract：:Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...

journal_title：Cells

authors： Celik-Selvi BE,Stütz A,Mayer CE,Salhi J,Siegwart G,Sutterlüty H

更新日期：2019-08-01 00:00:00

abstract：:Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade ...

journal_title：Cells

authors： Choi Y,Heo SC,Kim YN,Joo JY,Hwang JJ,Bae MK,Kim HJ

更新日期：2020-12-31 00:00:00

abstract：:Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its recepto...

journal_title：Cells

authors： Tang ZR,Zhang R,Lian ZX,Deng SL,Yu K

更新日期：2019-09-21 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been f...

journal_title：Cells

authors： Stackhouse CT,Gillespie GY,Willey CD

更新日期：2020-10-28 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Brain injury exosomal proteins are promising blood biomarker candidates in traumatic brain injury (TBI). A better understanding of their role in the diagnosis, characterization, and management of TBI is essential for upcoming clinical implementation. In the current investigation, we aimed to explore longitudinal traje...

journal_title：Cells

authors： Mondello S,Guedes VA,Lai C,Czeiter E,Amrein K,Kobeissy F,Mechref Y,Jeromin A,Mithani S,Martin C,Wagner CL,Czigler A,Tóth L,Fazekas B,Buki A,Gill J

更新日期：2020-04-15 00:00:00

abstract：:Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they fa...

journal_title：Cells

authors： Xuan P,Pan S,Zhang T,Liu Y,Sun H

更新日期：2019-08-30 00:00:00

abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...

journal_title：Cells

authors： Carotenuto P,Pecoraro A,Palma G,Russo G,Russo A

更新日期：2019-09-16 00:00:00

abstract：:The authors wish to make the following corrections to this paper [...]. ...

journal_title：Cells

authors： Nemade H,Acharya A,Chaudhari U,Nembo E,Nguemo F,Riet N,Abken H,Hescheler J,Papadopoulos S,Sachinidis A

更新日期：2020-09-24 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...

journal_title：Cells

authors： Syed SN,Raue R,Weigert A,von Knethen A,Brüne B

更新日期：2019-07-28 00:00:00

abstract：:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...

journal_title：Cells

authors： Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo E

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:In the fruit fly, Drosophila melanogaster, the larval somatic muscles or the adult thoracic flight and leg muscles are the major voluntary locomotory organs. They share several developmental and structural similarities with vertebrate skeletal muscles. To ensure appropriate activity levels for their functions such as ...

journal_title：Cells

authors： Poovathumkadavil P,Jagla K

更新日期：2020-06-25 00:00:00

abstract：:In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...

journal_title：Cells

authors： Felix L,Ziemens D,Seifert G,Rose CR

更新日期：2019-12-31 00:00:00

abstract：:Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits ...

journal_title：Cells

authors： Gleue L,Schupp J,Zimmer N,Becker E,Frey H,Tuettenberg A,Helm M

更新日期：2020-09-29 00:00:00

abstract：:The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their ro...

journal_title：Cells

authors： Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini A

更新日期：2014-08-05 00:00:00

abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...

journal_title：Cells

authors： Kolb K,Hellinger J,Kansy M,Wegwitz F,Bauerschmitz G,Emons G,Gründker C

更新日期：2020-12-05 00:00:00

abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...

journal_title：Cells

authors： Nascimento RA,Possomato-Vieira JS,Bonacio GF,Rizzi E,Dias-Junior CA

更新日期：2019-11-07 00:00:00

abstract：:Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...

journal_title：Cells

authors： Bovolenta LA,Pinhal D,Acencio ML,Oliveira AC,Moxon S,Martins C,Lemke N

更新日期：2020-07-22 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00