Abstract：
:The PIKfyve inhibitor apilimod is currently undergoing clinical trials for treatment of COVID-19. However, although apilimod might prevent viral invasion by inhibiting host cell proteases, the same proteases are critical for antigen presentation leading to T cell activation and there is good evidence from both in vitro studies and the clinic that apilimod blocks antiviral immune responses. We therefore warn that the immunosuppression observed in many COVID-19 patients might be aggravated by apilimod.
journal_name
Cellsjournal_title
Cellsauthors
Baranov MV,Bianchi F,van den Bogaart Gdoi
10.3390/cells10010030subject
Has Abstractpub_date
2020-12-27 00:00:00issue
1issn
2073-4409pii
cells10010030journal_volume
10pub_type
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