Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis.

abstract：:Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...

journal_title：Cells

authors： Lu C,Pang D,Li M,Yuan H,Yu T,Huang P,Li J,Chen X,Jiao H,Xie Z,Ouyang H

更新日期：2019-02-01 00:00:00

abstract：:Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...

journal_title：Cells

authors： Nouwen LV,Everts B

更新日期：2020-01-09 00:00:00

abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...

journal_title：Cells

authors： Chen X,Egly C,Riley AM,Li W,Tewson P,Hughes TE,Quinn AM,Obukhov AG

更新日期：2014-04-04 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Although clonal cytogenetic abnormalities can be detected by conventional cy...

journal_title：Cells

authors： Rangel-Pozzo A,Corrêa de Souza D,Schmid-Braz AT,de Azambuja AP,Ferraz-Aguiar T,Borgonovo T,Mai S

更新日期：2019-04-02 00:00:00

abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...

journal_title：Cells

authors： Aslam M,Ladilov Y

更新日期：2020-08-25 00:00:00

abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...

journal_title：Cells

authors： Papiewska-Pająk I,Krzyżanowski D,Katela M,Rivet R,Michlewska S,Przygodzka P,Kowalska MA,Brézillon S

更新日期：2020-06-30 00:00:00

abstract：:DNA methylation controls several cellular processes, from early development to old age, including biological responses to endogenous or exogenous stimuli contributing to disease transition. As a result, minimal DNA methylation changes during developmental stages drive severe phenotypes, as observed in germ-line imprin...

journal_title：Cells

authors： Borchiellini M,Ummarino S,Di Ruscio A

更新日期：2019-10-12 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...

journal_title：Cells

authors： Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

更新日期：2020-04-04 00:00:00

abstract：:This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...

journal_title：Cells

authors： Idrees M,Xu L,Song SH,Joo MD,Lee KL,Muhammad T,El Sheikh M,Sidrat T,Kong IK

更新日期：2019-10-18 00:00:00

abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...

journal_title：Cells

authors： Fossati G,Matteoli M,Menna E

更新日期：2020-09-26 00:00:00

abstract：:As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...

journal_title：Cells

authors： López-Ruiz BA,Zluhan-Martínez E,Sánchez MP,Álvarez-Buylla ER,Garay-Arroyo A

更新日期：2020-12-01 00:00:00

abstract：:Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...

journal_title：Cells

authors： Saccenti L,Hagiwara A,Andica C,Yokoyama K,Fujita S,Kato S,Maekawa T,Kamagata K,Le Berre A,Hori M,Wada A,Tateishi U,Hattori N,Aoki S

更新日期：2020-02-08 00:00:00

abstract：:β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac fu...

journal_title：Cells

authors： Laudette M,Formoso K,Lezoualc'h F

更新日期：2021-01-14 00:00:00

abstract：:Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been identified in tunicates, an early chordate. To obtain a detailed insight into the ...

journal_title：Cells

authors： Akula S,Paivandy A,Fu Z,Thorpe M,Pejler G,Hellman L

更新日期：2020-01-14 00:00:00

abstract：:Embryoid bodies (EBs) resemble self-organizing aggregates of pluripotent stem cells that recapitulate some aspects of early embryogenesis. Within few days, the cells undergo a transition from rather homogeneous epithelial-like pluripotent stem cell colonies into a three-dimensional organization of various cell types w...

journal_title：Cells

authors： Zeevaert K,Elsafi Mabrouk MH,Wagner W,Goetzke R

更新日期：2020-10-11 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...

journal_title：Cells

authors： Lee Y,Kim SJ,Choo J,Heo G,Yoo JW,Jung Y,Rhee SH,Im E

更新日期：2020-06-01 00:00:00

abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...

journal_title：Cells

authors： Umair M,Alfadhel M

更新日期：2019-12-09 00:00:00

abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...

journal_title：Cells

authors： Hu LL,Chang HM,Yi Y,Liu Y,Taylor EL,Zheng LP,Leung PCK

更新日期：2019-11-15 00:00:00

abstract：:The current coronavirus disease-2019 (COVID-19) pandemic is due to the novel coronavirus SARS-CoV-2. The scientific community has mounted a strong response by accelerating research and innovation, and has quickly set the foundation for understanding the molecular determinants of the disease for the development of targ...

journal_title：Cells

authors： Romano M,Ruggiero A,Squeglia F,Maga G,Berisio R

更新日期：2020-05-20 00:00:00

abstract：:Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...

journal_title：Cells

authors： Navarro-Romero A,Montpeyó M,Martinez-Vicente M

更新日期：2020-11-02 00:00:00

abstract：:Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll-/-) exhibit elevated tissue levels of MAGs in association with res...

journal_title：Cells

authors： Dione N,Lacroix S,Taschler U,Deschênes T,Abolghasemi A,Leblanc N,Di Marzo V,Silvestri C

更新日期：2020-12-17 00:00:00

abstract：:Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...

journal_title：Cells

authors： Picca A,Saini SK,Mankowski RT,Kamenov G,Anton SD,Manini TM,Buford TW,Wohlgemuth SE,Xiao R,Calvani R,Coelho-Júnior HJ,Landi F,Bernabei R,Hood DA,Marzetti E,Leeuwenburgh C

更新日期：2020-12-02 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries with almost 25% affected adults worldwide. The growing public health burden is getting evident when considering that NAFLD-related liver transplantations are predicted to almost double within the next 20 years. Typic...

journal_title：Cells

authors： Drescher HK,Weiskirchen S,Weiskirchen R

更新日期：2019-08-07 00:00:00

abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...

journal_title：Cells

authors： Legartová S,Lochmanová G,Zdráhal Z,Kozubek S,Šponer J,Krepl M,Pokorná P,Bártová E

更新日期：2019-09-17 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...

journal_title：Cells

authors： Vaeteewoottacharn K,Pairojkul C,Kariya R,Muisuk K,Imtawil K,Chamgramol Y,Bhudhisawasdi V,Khuntikeo N,Pugkhem A,Saeseow OT,Silsirivanit A,Wongkham C,Wongkham S,Okada S

更新日期：2019-05-23 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...

journal_title：Cells

authors： Chu YH,Su CW,Hsieh YS,Chen PN,Lin CW,Yang SF

更新日期：2020-03-13 00:00:00

abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

journal_title：Cells

authors： Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

更新日期：2019-05-08 00:00:00

abstract：:Breast cancer-related mortality remains high worldwide, despite tremendous advances in diagnostics and therapeutics; hence, the quest for better strategies for disease management, as well as the identification of modifiable risk factors, continues. With recent leaps in genomic technologies, microbiota have emerged as ...

journal_title：Cells

authors： Parida S,Sharma D

更新日期：2020-04-28 00:00:00