Current Status in Testing for Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH).

Abstract:

:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries with almost 25% affected adults worldwide. The growing public health burden is getting evident when considering that NAFLD-related liver transplantations are predicted to almost double within the next 20 years. Typically, hepatic alterations start with simple steatosis, which easily progresses to more advanced stages such as nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. This course of disease finally leads to end-stage liver disease such as hepatocellular carcinoma, which is associated with increased morbidity and mortality. Although clinical trials show promising results, there is actually no pharmacological agent approved to treat NASH. Another important problem associated with NASH is that presently the liver biopsy is still the gold standard in diagnosis and for disease staging and grading. Because of its invasiveness, this technique is not well accepted by patients and the method is prone to sampling error. Therefore, an urgent need exists to find reliable, accurate and noninvasive biomarkers discriminating between different disease stages or to develop innovative imaging techniques to quantify steatosis.

journal_name

Cells

journal_title

Cells

authors

Drescher HK,Weiskirchen S,Weiskirchen R

doi

10.3390/cells8080845

subject

Has Abstract

pub_date

2019-08-07 00:00:00

issue

8

issn

2073-4409

pii

cells8080845

journal_volume

8

pub_type

杂志文章,评审

相关文献

Cells文献大全
  • Convolutional Neural Networks-Based Image Analysis for the Detection and Quantification of Neutrophil Extracellular Traps.

    abstract::Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspecific dyes and technical difficulties. Therefore, we aimed to develop...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020508

    authors: Manda-Handzlik A,Fiok K,Cieloch A,Heropolitanska-Pliszka E,Demkow U

    更新日期:2020-02-24 00:00:00

  • Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain.

    abstract::As a non-antibody scaffold, monobodies based on the fibronectin type III (FN3) domain overcome antibody size and complexity while maintaining analogous binding loops. However, antibodies and their derivatives remain the gold standard for the design of new therapeutics. In response, clinical-stage therapeutic proteins ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030610

    authors: Chandler PG,Buckle AM

    更新日期:2020-03-04 00:00:00

  • The Role of GLP1 in Rat Steatotic and Non-Steatotic Liver Transplantation from Cardiocirculatory Death Donors.

    abstract::In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8121599

    authors: Avalos-de León CG,Jiménez-Castro MB,Cornide-Petronio ME,Casillas-Ramírez A,Peralta C

    更新日期:2019-12-09 00:00:00

  • GhVTC1, the Key Gene for Ascorbate Biosynthesis in Gossypium hirsutum, Involves in Cell Elongation Under Control of Ethylene.

    abstract::L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8091039

    authors: Song W,Wang F,Chen L,Ma R,Zuo X,Cao A,Xie S,Chen X,Jin X,Li H

    更新日期:2019-09-05 00:00:00

  • Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma.

    abstract::The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020500

    authors: Wai KC,Strohl MP,van Zante A,Ha PK

    更新日期:2020-02-22 00:00:00

  • Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells.

    abstract::The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8060625

    authors: Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

    更新日期:2019-06-21 00:00:00

  • A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope.

    abstract::The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9091989

    authors: Luteijn RD,Praest P,Thiele F,Sadasivam SM,Singethan K,Drijfhout JW,Bach C,de Boer SM,Lebbink RJ,Tao S,Helfer M,Bach NC,Protzer U,Costa AI,Killian JA,Drexler I,Wiertz EJHJ

    更新日期:2020-08-29 00:00:00

  • Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity.

    abstract::Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020367

    authors: Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

    更新日期:2020-02-05 00:00:00

  • Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.

    abstract::Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8070660

    authors: Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

    更新日期:2019-06-30 00:00:00

  • Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders.

    abstract::Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020358

    authors: Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

    更新日期:2020-02-04 00:00:00

  • Creatine Kinase and Progression Rate in Amyotrophic Lateral Sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9051174

    authors: Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

    更新日期:2020-05-08 00:00:00

  • Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells.

    abstract::Insulin and insulin-like growth factor-1 (IGF1) have important roles in breast cancer development. The recent identification of nuclear insulin (INSR) and IGF1 (IGF1R) receptors provides a novel paradigm in the area of signal transduction. The fact that INSR and IGF1R can function as transcription factors, capable of ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8121499

    authors: Sarfstein R,Nagaraj K,LeRoith D,Werner H

    更新日期:2019-11-23 00:00:00

  • Reading between the (Genetic) Lines: How Epigenetics is Unlocking Novel Therapies for Type 1 Diabetes.

    abstract::Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9112403

    authors: Akil AA,Jerman LF,Yassin E,Padmajeya SS,Al-Kurbi A,Fakhro KA

    更新日期:2020-11-03 00:00:00

  • Exploring MicroRNA Biomarkers for Parkinson's Disease from mRNA Expression Profiles.

    abstract::Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients' signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In t...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells7120245

    authors: Taguchi YH,Wang H

    更新日期:2018-12-05 00:00:00

  • Automated Counting of Cancer Cells by Ensembling Deep Features.

    abstract::High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8091019

    authors: Liu Q,Junker A,Murakami K,Hu P

    更新日期:2019-09-02 00:00:00

  • MicroRNAs as a Potential Quality Measurement Tool of Platelet Concentrate Stored in Blood Banks-A Review.

    abstract:BACKGROUND:Platelet concentrate (PC) is one of the main products used in a therapeutic transfusion. This blood component requires special storage at blood banks, however, even under good storage conditions, modifications or degradations may occur and are known as platelet storage lesions. METHODS:This research was per...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8101256

    authors: Maués JHDS,Aquino Moreira-Nunes CF,Rodriguez Burbano RM

    更新日期:2019-10-15 00:00:00

  • Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future.

    abstract::Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells10010117

    authors: Minciacchi VR,Kumar R,Krause DS

    更新日期:2021-01-10 00:00:00

  • Roles of the Hepatic Endocannabinoid and Apelin Systems in the Pathogenesis of Liver Fibrosis.

    abstract::Hepatic fibrosis is the consequence of an unresolved wound healing process in response to chronic liver injury and involves multiple cell types and molecular mechanisms. The hepatic endocannabinoid and apelin systems are two signalling pathways with a substantial role in the liver fibrosis pathophysiology-both are upr...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8111311

    authors: Melgar-Lesmes P,Perramon M,Jiménez W

    更新日期:2019-10-24 00:00:00

  • Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.

    abstract::Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation, adhesion, morphology, exocytosis, and gene expression. As a result,...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8111425

    authors: Beck EM,Parnell E,Cowley A,Porter A,Gillespie J,Robinson J,Robinson L,Pannifer AD,Hamon V,Jones P,Morrison A,McElroy S,Timmerman M,Rutjes H,Mahajan P,Wiejak J,Luchowska-Stańska U,Morgan D,Barker G,Rehmann H,Yarwoo

    更新日期:2019-11-12 00:00:00

  • Limited Proteolysis-Coupled Mass Spectrometry Identifies Phosphatidylinositol 4,5-Bisphosphate Effectors in Human Nuclear Proteome.

    abstract::Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear functional domains. We performed limited proteolysis followed by ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells10010068

    authors: Sztacho M,Šalovská B,Červenka J,Balaban C,Hoboth P,Hozák P

    更新日期:2021-01-04 00:00:00

  • Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers.

    abstract::Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells10020215

    authors: Khan S,Ricciardelli C,Yool AJ

    更新日期:2021-01-22 00:00:00

  • Structure and Function of Human Matrix Metalloproteinases.

    abstract::The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9051076

    authors: Laronha H,Caldeira J

    更新日期:2020-04-26 00:00:00

  • Cells in Cardiovascular Disease: Using Diversity to Confront Adversity.

    abstract::The present Special Issue on "Cells in Cardiovascular Disease" wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory system [...]. ...

    journal_title:Cells

    pub_type: 社论

    doi:10.3390/cells9102192

    authors: Martínez-González J,García de Frutos P

    更新日期:2020-09-29 00:00:00

  • Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease.

    abstract::Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020470

    authors: Raasakka A,Kursula P

    更新日期:2020-02-18 00:00:00

  • A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.

    abstract::The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaini...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9071678

    authors: Rahman S,Canny MD,Buschmann TA,Latham MP

    更新日期:2020-07-13 00:00:00

  • In Vivo TSPO Signal and Neuroinflammation in Alzheimer's Disease.

    abstract::In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9091941

    authors: Tournier BB,Tsartsalis S,Ceyzériat K,Garibotto V,Millet P

    更新日期:2020-08-21 00:00:00

  • TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision.

    abstract::Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells3030914

    authors: Ryskamp DA,Redmon S,Jo AO,Križaj D

    更新日期:2014-09-12 00:00:00

  • Cancer Biogenesis in Ribosomopathies.

    abstract::Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8030229

    authors: Sulima SO,Kampen KR,De Keersmaecker K

    更新日期:2019-03-11 00:00:00

  • Regulation of MT1-MMP Activity through Its Association with ERMs.

    abstract::Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorpo...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020348

    authors: Suárez H,López-Martín S,Toribio V,Zamai M,Hernández-Riquer MV,Genís L,Arroyo AG,Yáñez-Mó M

    更新日期:2020-02-03 00:00:00

  • Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury.

    abstract::Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells7100178

    authors: Andrianova NV,Jankauskas SS,Zorova LD,Pevzner IB,Popkov VA,Silachev DN,Plotnikov EY,Zorov DB

    更新日期:2018-10-22 00:00:00