Abstract:
:The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Although clonal cytogenetic abnormalities can be detected by conventional cytogenetics in 50% of patients with MDS, such distinguishing patterns are lacking in the other 50%. Despite the increase in the prognostic value of some biomarkers, none of them is specific and able to discriminate between stable and unstable patients that subsequently progress to acute myeloid leukemia. This pilot study aimed to investigate the potential use of the 3D telomere profiling to detect genomic instability in MDS patients with or without clonal cytogenetic evolution. The comparison between different time points in patients with cytogenetic changes showed that in the CD34+ MDS cells, there was a significant decrease in the total number of telomeric signals, the average intensity of signals and the total intensity of telomeres. By contrast, the number of aggregates increased during cytogenetic evolution (p < 0.001). This pattern was observed only for MDS patients with cytogenetic evolution but was absent in patients without cytogenetic changes. In conclusion, we demonstrated that the 3D nuclear telomere organization was significantly altered during the MDS disease course, and may have contributed to cytogenetic clonal evolution.
journal_name
Cellsjournal_title
Cellsauthors
Rangel-Pozzo A,Corrêa de Souza D,Schmid-Braz AT,de Azambuja AP,Ferraz-Aguiar T,Borgonovo T,Mai Sdoi
10.3390/cells8040304subject
Has Abstractpub_date
2019-04-02 00:00:00issue
4issn
2073-4409pii
cells8040304journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract:BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122558
更新日期:2020-11-29 00:00:00
abstract::Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have previously been suggested to play a role in the complex cascade ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010050
更新日期:2020-12-31 00:00:00
abstract::Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112389
更新日期:2020-10-31 00:00:00
abstract::Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061503
更新日期:2020-06-20 00:00:00
abstract::Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080888
更新日期:2019-08-13 00:00:00
abstract::The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122584
更新日期:2020-12-02 00:00:00
abstract::Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020362
更新日期:2020-02-04 00:00:00
abstract::Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a ma...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010128
更新日期:2020-01-06 00:00:00
abstract::Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9051294
更新日期:2020-05-22 00:00:00
abstract::Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091919
更新日期:2020-08-19 00:00:00
abstract::Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been f...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112369
更新日期:2020-10-28 00:00:00
abstract::The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070687
更新日期:2019-07-07 00:00:00
abstract::Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102200
更新日期:2020-09-29 00:00:00
abstract::Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112525
更新日期:2020-11-23 00:00:00
abstract::Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10020215
更新日期:2021-01-22 00:00:00
abstract::Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation and the scavenging of reactive species...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8010064
更新日期:2019-01-17 00:00:00
abstract::Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060585
更新日期:2019-06-14 00:00:00
abstract::Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050422
更新日期:2019-05-08 00:00:00
abstract::Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010191
更新日期:2020-01-11 00:00:00
abstract::Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060601
更新日期:2019-06-17 00:00:00
abstract::Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050449
更新日期:2019-05-13 00:00:00
abstract::The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051296
更新日期:2020-05-22 00:00:00
abstract::Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which als...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020470
更新日期:2020-02-18 00:00:00
abstract::The discovery of the isocitrate dehydrogenase (IDH) mutation in glioma led to a paradigm shift on how we see glioma biology. Difficulties in cultivating IDH mutant glioma stem cells (IDHmut GSCs) resulted in a paucity of preclinical models in IDHmut glioma, limiting the discovery of new effective chemotherapeutic agen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061389
更新日期:2020-06-03 00:00:00
abstract::The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102298
更新日期:2020-10-15 00:00:00
abstract::Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010085
更新日期:2021-01-07 00:00:00
abstract::The aggregation of proteins compromises cell fitness, either because it titrates functional proteins into non-productive inclusions or because it results in the formation of toxic assemblies. Accordingly, computational proteome-wide analyses suggest that prevention of aggregation upon misfolding plays a key role in se...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080856
更新日期:2019-08-08 00:00:00
abstract::Chronic inflammation and abnormalities in Toll-like receptor (TLR) signaling pathways are associated with major depressive disorder (MDD). Our previous work reported that impaired negative regulators for the TLR pathways are associated with MDD. This study aimed to assess the association between the severity of depres...
journal_title:Cells
pub_type: 临床试验,杂志文章
doi:10.3390/cells8070647
更新日期:2019-06-27 00:00:00
abstract::We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092015
更新日期:2020-09-02 00:00:00
abstract::The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9122580
更新日期:2020-12-02 00:00:00