Abstract:
:Chronic inflammation and abnormalities in Toll-like receptor (TLR) signaling pathways are associated with major depressive disorder (MDD). Our previous work reported that impaired negative regulators for the TLR pathways are associated with MDD. This study aimed to assess the association between the severity of depression and the intracellular microRNAs that regulate TLR4 signaling in both peripheral blood mononuclear cells (PBMCs) and monocytes from MDD patients. The severity of MDD before and after antidepressant treatment was determined by the 17-item Hamilton Depression Rating Scale, and quantitative RT-PCR was used to measure the levels of intracellular regulatory microRNAs, including let-7e, miR-21-5p miR-145, miR-223, miR-146a, and miR-155, in PBMCs and monocytes isolated from 43 healthy controls and 84 patients with MDD before and after treatment with antidepressants. Assays of PBMCs showed that the levels of let-7e, miR-146a, and miR-155 were lower in MDD patients than in healthy controls and were significantly higher after than before treatment in the 69 patients who completed treatment with antidepressants for four weeks. Levels of miR-146a and miR-155 in monocytes were lower in MDD patients than in controls and were increased in the former after antidepressant treatment. Multiple linear regression analyses found that let-7e and miR-146a expression before treatment was inversely correlated with severity of depression, whereas miR-155 before treatment was directly correlated with severity of depression. These findings suggest that intracellular regulatory microRNAs which regulate TLR4 signaling are aberrantly expressed in patients with MDD and that these levels are ameliorated by antidepressant treatment.
journal_name
Cellsjournal_title
Cellsauthors
Hung YY,Wu MK,Tsai MC,Huang YL,Kang HYdoi
10.3390/cells8070647subject
Has Abstractpub_date
2019-06-27 00:00:00issue
7issn
2073-4409pii
cells8070647journal_volume
8pub_type
临床试验,杂志文章相关文献
Cells文献大全abstract::The pathophysiology of diabetic nephropathy (DN), one of the most serious complications in diabetic patients and the leading cause of end-stage renal disease worldwide, is complex and not fully elucidated. A typical hallmark of DN is the excessive deposition of extracellular matrix (ECM) proteins in the glomerulus and...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells4040631
更新日期:2015-10-09 00:00:00
abstract::YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic lupus erythematosus and Sjögren's syndrome. Deregulation of YRNAs...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051281
更新日期:2020-05-21 00:00:00
abstract::The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080920
更新日期:2019-08-17 00:00:00
abstract::Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8060543
更新日期:2019-06-05 00:00:00
abstract::Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed for regenerative medicine, cardiovascular research, and pharmacological studies. However, the differentiation of adult MSC into a cardiac lineage is challenging compared to ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020504
更新日期:2020-02-22 00:00:00
abstract::Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020393
更新日期:2020-02-08 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7050038
更新日期:2018-05-08 00:00:00
abstract::Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101264
更新日期:2019-10-16 00:00:00
abstract::The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for bo...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102144
更新日期:2020-09-23 00:00:00
abstract::Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020367
更新日期:2020-02-05 00:00:00
abstract::Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020312
更新日期:2020-01-28 00:00:00
abstract::During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020097
更新日期:2019-01-29 00:00:00
abstract::TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081847
更新日期:2020-08-06 00:00:00
abstract::In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. Here, we...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051087
更新日期:2020-04-28 00:00:00
abstract::The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050404
更新日期:2019-05-01 00:00:00
abstract::Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles. Centrosomes serve as major microtubule- and actin cytoskeleton-organizing centers and are involved in a variety of intracellular pr...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070701
更新日期:2019-07-10 00:00:00
abstract::Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010161
更新日期:2020-01-09 00:00:00
abstract::: T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivation, suppression by T regulatory cells (Treg), induction of expressi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020154
更新日期:2019-02-12 00:00:00
abstract::Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091087
更新日期:2019-09-14 00:00:00
abstract::Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060053
更新日期:2018-06-02 00:00:00
abstract::Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells6010006
更新日期:2017-02-10 00:00:00
abstract::There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121605
更新日期:2019-12-11 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081793
更新日期:2020-07-28 00:00:00
abstract::Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040870
更新日期:2020-04-02 00:00:00
abstract::Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8030229
更新日期:2019-03-11 00:00:00
abstract::Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020358
更新日期:2020-02-04 00:00:00
abstract::The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV patients live longer. Deposition of beta-amyloid (Aβ), a hallmark of Alzheimer's disease (AD), has been observed in subjects with HIV-associat...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8090968
更新日期:2019-08-24 00:00:00
abstract::Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on the effect of calcit...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112440
更新日期:2020-11-09 00:00:00
abstract::Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7110221
更新日期:2018-11-21 00:00:00
abstract::Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102148
更新日期:2020-09-23 00:00:00