Abstract：
:The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for both thermal and fast neutron doses, although such an approach has been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam has been used to determine thermal neutron relative biological effectiveness factors. Different cancer cell lines, which correspond to glioblastoma, melanoma, and head and neck squamous cell carcinoma, and non-tumor cell lines (lung fibroblast and embryonic kidney), have been irradiated while using an experimental arrangement designed to minimize neutron-induced secondary gamma radiation. Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference data for comparison with that from neutron irradiation. The survival and proliferation were studied after irradiation, yielding the Relative Biological Effectiveness that corresponds to the damage of thermal neutrons for the different tissue types.
journal_name
Cellsjournal_title
Cellsauthors
Pedrosa-Rivera M,Praena J,Porras I,Sabariego MP,Köster U,Haertlein M,Forsyth VT,Ramírez JC,Jover C,Jimena D,Osorio JL,Álvarez P,Ruiz-Ruiz C,Ruiz-Magaña MJdoi
10.3390/cells9102144subject
Has Abstractpub_date
2020-09-23 00:00:00issue
10issn
2073-4409pii
cells9102144journal_volume
9pub_type
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