EpCAM as Modulator of Tissue Plasticity.

abstract：:The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...

journal_title：Cells

authors： Albakova Z,Armeev GA,Kanevskiy LM,Kovalenko EI,Sapozhnikov AM

更新日期：2020-03-02 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...

journal_title：Cells

authors： Zheng F,Phelan KD

更新日期：2014-04-09 00:00:00

abstract：:Microalgae have emerged as a promising platform for production of carbon- and energy- rich molecules, notably starch and oil. Establishing an economically viable algal biotechnology sector requires a holistic understanding of algal photosynthesis, physiology, cell cycle and metabolism. Starch/oil productivity is a com...

journal_title：Cells

authors： Burlacot A,Peltier G,Li-Beisson Y

更新日期：2019-09-26 00:00:00

abstract：:Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...

journal_title：Cells

authors： Kosyna FK,Depping R

更新日期：2018-11-21 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Human Vγ9Vδ2 γδ T cells can kill a variety of cancer cells and have attracted substantial interest for cancer immunotherapy. Toll-like receptor (TLR) ligands are promising adjuvants for cancer immunotherapy, but TLR7/8 ligand Resiquimod has been shown to inhibit CD4 T-cell activation in a monocyte-dependent ...

journal_title：Cells

authors： Serrano R,Wesch D,Kabelitz D

更新日期：2020-03-13 00:00:00

abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

journal_title：Cells

authors： Laronha H,Caldeira J

更新日期：2020-04-26 00:00:00

abstract：:Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that th...

journal_title：Cells

authors： Ruksha K,Mezheyeuski A,Nerovnya A,Bich T,Tur G,Gorgun J,Luduena R,Portyanko A

更新日期：2019-01-07 00:00:00

abstract：:Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We report reduced protein ...

journal_title：Cells

authors： Gallego P,Castejón-Vega B,Del Campo JA,Cordero MD

更新日期：2020-09-23 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00

abstract：:Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...

journal_title：Cells

authors： Huang HC,Cai BH,Suen CS,Lee HY,Hwang MJ,Liu FT,Kannagi R

更新日期：2020-02-09 00:00:00

abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...

journal_title：Cells

authors： Sun Y,Cai Y,Zang QS

更新日期：2019-02-10 00:00:00

abstract：:One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs)...

journal_title：Cells

authors： Rauter T,Burgstaller S,Gottschalk B,Ramadani-Muja J,Bischof H,Hay JC,Graier WF,Malli R

更新日期：2020-10-17 00:00:00

abstract：:Alcoholic fatty liver disease (AFLD) is characterized by an abnormal accumulation of lipid droplets (LDs) in the liver. Here, we explore the composition of hepatic LDs in a rat model of AFLD. Five to seven weeks of alcohol consumption led to significant increases in hepatic triglyceride mass, along with increases in L...

journal_title：Cells

authors： Listenberger L,Townsend E,Rickertsen C,Hains A,Brown E,Inwards EG,Stoeckman AK,Matis MP,Sampathkumar RS,Osna NA,Kharbanda KK

更新日期：2018-11-24 00:00:00

abstract：:The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions thro...

journal_title：Cells

authors： Gundogdu R,Hergovich A

更新日期：2019-06-10 00:00:00

abstract：:The nuclear envelope (NE) consists of the inner and outer nuclear membranes (INM and ONM), and the nuclear pore complex (NPC), which penetrates the double membrane. ONM continues with the endoplasmic reticulum (ER). INM and NPC can interact with chromatin to regulate the genetic activities of the chromosome. Studies i...

journal_title：Cells

authors： Hirano Y,Asakawa H,Sakuno T,Haraguchi T,Hiraoka Y

更新日期：2020-08-16 00:00:00

abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...

journal_title：Cells

authors： Osei ET,Booth S,Hackett TL

更新日期：2020-07-15 00:00:00

abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

journal_title：Cells

authors： Fields GB

更新日期：2019-08-27 00:00:00

abstract：:Cannabidiol (CBD), as the only phytocannabinoid that has no psychoactive effect, has both antioxidant and anti-inflammatory effects, and thus might be suggested as a cytoprotective compound against UV-induced metabolic changes in skin cells. Therefore, the aim of this study was to investigate the level of protective C...

journal_title：Cells

authors： Gęgotek A,Atalay S,Domingues P,Skrzydlewska E

更新日期：2019-08-28 00:00:00

abstract：:Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...

journal_title：Cells

authors： Andrianova NV,Jankauskas SS,Zorova LD,Pevzner IB,Popkov VA,Silachev DN,Plotnikov EY,Zorov DB

更新日期：2018-10-22 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are a...

journal_title：Cells

authors： Puentes-Rozo PJ,Acosta-López JE,Cervantes-Henríquez ML,Martínez-Banfi ML,Mejia-Segura E,Sánchez-Rojas M,Anaya-Romero ME,Acosta-Hoyos A,García-Llinás GA,Mastronardi CA,Pineda DA,Castellanos FX,Arcos-Burgos M,Vélez JI

更新日期：2019-08-16 00:00:00

abstract：:Notch receptors are single-pass transmembrane proteins that play a critical role in cell fate decisions and have been implicated in the regulation of many developmental processes. The human Notch family comprises of four receptors (Notch 1 to 4) and five ligands. Their signaling can regulate extremely basic cellular p...

journal_title：Cells

authors： Gragnani L,Lorini S,Marri S,Zignego AL

更新日期：2020-12-24 00:00:00

abstract：:All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in the proteasome, mediated by three types of ubiquitin enzymes: E1...

journal_title：Cells

authors： Su T,Yang M,Wang P,Zhao Y,Ma C

更新日期：2020-10-01 00:00:00

abstract：:Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...

journal_title：Cells

authors： Gurevich EV,Gurevich VV

更新日期：2020-12-31 00:00:00

abstract：:Plasma exosomal microRNAs (miRNAs) are considered as valid circulating biomarkers for cancer diagnosis and prognosis. Quantitative real-time polymerase chain reaction (qRT-PCR), the most commonly used technique to assess circulating miRNA levels, requires a normalization step involving uniformly expressed endogenous m...

journal_title：Cells

authors： Damanti CC,Gaffo E,Lovisa F,Garbin A,Di Battista P,Gallingani I,Tosato A,Pillon M,Carraro E,Mascarin M,Elia C,Biffi A,Bortoluzzi S,Mussolin L

更新日期：2021-01-08 00:00:00

abstract：:Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...

journal_title：Cells

authors： Fritzen AM,Thøgersen FB,Thybo K,Vissing CR,Krag TO,Ruiz-Ruiz C,Risom L,Wibrand F,Høeg LD,Kiens B,Duno M,Vissing J,Jeppesen TD

更新日期：2019-03-12 00:00:00

abstract：:More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...

journal_title：Cells

authors： Kang JH,Lee SH,Lee JS,Oh SJ,Ha JS,Choi HJ,Kim SY

更新日期：2020-06-16 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00