Abstract：
:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is suggested to be engaged in the pathogenesis of major depressive disorder, and to be a target and/or modifier of anti-depressants' action. In this review, we discuss abnormalities in the activity of GSK3β and its upstream regulators in different brain regions during depressive episodes. Additionally, putative role(s) of GSK3β in the pathogenesis of depression and the influence of anti-depressants on GSK3β activity are discussed.
journal_name
Cellsjournal_title
Cellsauthors
Duda P,Hajka D,Wójcicka O,Rakus D,Gizak Adoi
10.3390/cells9030727subject
Has Abstractpub_date
2020-03-16 00:00:00issue
3issn
2073-4409pii
cells9030727journal_volume
9pub_type
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