Special Issue on "Disease and the Hippo Pathway".

abstract：:Pharmaco-therapeutic strategies of atrial fibrillation (AF) are moderately effective and do not prevent AF onset and progression. Therefore, there is an urgent need to develop novel therapies. Previous studies revealed heat shock protein (HSP)-inducing compounds to mitigate AF onset and progression. Such an HSP induci...

journal_title：Cells

authors： Starreveld R,Ramos KS,Muskens AJQM,Brundel BJJM,de Groot NMS

更新日期：2020-07-20 00:00:00

abstract：:One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs)...

journal_title：Cells

authors： Rauter T,Burgstaller S,Gottschalk B,Ramadani-Muja J,Bischof H,Hay JC,Graier WF,Malli R

更新日期：2020-10-17 00:00:00

abstract：:The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes reportedly share with circular RNAs (circRNAs). Interestingly, some ...

journal_title：Cells

authors： Mfossa ACM,Thekkekara Puthenparampil H,Inalegwu A,Coolkens A,Baatout S,Benotmane MA,Huylebroeck D,Quintens R

更新日期：2019-07-26 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...

journal_title：Cells

authors： Palmerini E,Setola E,Grignani G,D'Ambrosio L,Comandone A,Righi A,Longhi A,Cesari M,Paioli A,Hakim R,Pierini M,Marchesi E,Vanel D,Pignochino Y,Donati DM,Picci P,Ferrari S

更新日期：2020-10-31 00:00:00

abstract：:The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for bo...

journal_title：Cells

authors： Pedrosa-Rivera M,Praena J,Porras I,Sabariego MP,Köster U,Haertlein M,Forsyth VT,Ramírez JC,Jover C,Jimena D,Osorio JL,Álvarez P,Ruiz-Ruiz C,Ruiz-Magaña MJ

更新日期：2020-09-23 00:00:00

abstract：:Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastom...

journal_title：Cells

authors： Karatsai O,Shliaha P,Jensen ON,Stasyk O,Rędowicz MJ

更新日期：2020-09-30 00:00:00

abstract：:Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Escherichia coli (E. coli) has long been a popular model organism for basic biological research. In this paper, weighted gene co-expression network analysis (WGCNA) algorithm was ap...

journal_title：Cells

authors： Liu W,Li L,Long X,You W,Zhong Y,Wang M,Tao H,Lin S,He H

更新日期：2018-03-08 00:00:00

abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...

journal_title：Cells

authors： Huaman J,Naidoo M,Zang X,Ogunwobi OO

更新日期：2019-06-20 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...

journal_title：Cells

authors： Laganà M,Schlecht-Louf G,Bachelerie F

更新日期：2021-01-05 00:00:00

abstract：:P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...

journal_title：Cells

authors： Kadioglu O,Efferth T

更新日期：2019-10-21 00:00:00

abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...

journal_title：Cells

authors： Bot I,Velden DV,Bouwman M,Kröner MJ,Kuiper J,Quax PHA,de Vries MR

更新日期：2020-03-12 00:00:00

abstract：:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...

journal_title：Cells

authors： Cha YJ,Koo JS

更新日期：2020-07-27 00:00:00

abstract：:As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on gliobl...

journal_title：Cells

authors： Riboni L,Abdel Hadi L,Navone SE,Guarnaccia L,Campanella R,Marfia G

更新日期：2020-02-01 00:00:00

abstract：:Cytokine dysregulation is characteristic of systemic lupus erythematosus (SLE), a systemic autoimmune disease of considerable heterogeneity. Insights gained about the cytokine dysregulation in SLE have the potential for identifying patient subsets before the onset of clinical disease and during established disease. Cl...

journal_title：Cells

authors： Howe HS,Leung BPL

更新日期：2019-12-27 00:00:00

abstract：:Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....

journal_title：Cells

authors： Tikhomirov R,Donnell BR,Catapano F,Faggian G,Gorelik J,Martelli F,Emanueli C

更新日期：2020-03-02 00:00:00

abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...

journal_title：Cells

authors： Sehadova H,Takasu Y,Zaloudikova A,Lin YH,Sauman I,Sezutsu H,Rouhova L,Kodrik D,Zurovec M

更新日期：2020-12-11 00:00:00

abstract：:Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...

journal_title：Cells

authors： Duan TL,He GJ,Hu LD,Yan YB

更新日期：2019-08-05 00:00:00

abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...

journal_title：Cells

authors： Cheng CL,Yang SC,Lai CY,Wang CK,Chang CF,Lin CY,Chen WJ,Lin PY,Wu HC,Ma N,Lu FL,Lu J

更新日期：2020-07-16 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interes...

journal_title：Cells

authors： Dai Z

更新日期：2019-07-20 00:00:00

abstract：:Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...

journal_title：Cells

authors： Yen JH,Lin CY,Chuang CH,Chin HK,Wu MJ,Chen PY

更新日期：2020-04-03 00:00:00

abstract：:Mast cells are long-lived, granular, myeloid-derived leukocytes that have significant protective and repair functions in tissues. Mast cells sense disruptions in the local microenvironment and are first responders to physical, chemical and biological insults. When activated, mast cells release growth factors, protease...

journal_title：Cells

authors： Willows S,Kulka M

更新日期：2020-12-18 00:00:00

abstract：:High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...

journal_title：Cells

authors： Liu Q,Junker A,Murakami K,Hu P

更新日期：2019-09-02 00:00:00

abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...

journal_title：Cells

authors： Farrag M,Leipzig ND

更新日期：2018-10-17 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...

journal_title：Cells

authors： Rinkenbaugh AL,Baldwin AS

更新日期：2016-04-06 00:00:00

abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

journal_title：Cells

authors： Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

更新日期：2019-06-21 00:00:00

abstract：:Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...

journal_title：Cells

authors： Fritzen AM,Thøgersen FB,Thybo K,Vissing CR,Krag TO,Ruiz-Ruiz C,Risom L,Wibrand F,Høeg LD,Kiens B,Duno M,Vissing J,Jeppesen TD

更新日期：2019-03-12 00:00:00