Construction and Analysis of Gene Co-Expression Networks in Escherichia coli.

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...

journal_title：Cells

authors： Akil AA,Jerman LF,Yassin E,Padmajeya SS,Al-Kurbi A,Fakhro KA

更新日期：2020-11-03 00:00:00

abstract：:A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...

journal_title：Cells

authors： Edin ML,Lih FB,Hammock BD,Thomson S,Zeldin DC,Bishop-Bailey D

更新日期：2020-04-29 00:00:00

abstract：:Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or...

journal_title：Cells

authors： Schulze-Tanzil G,Al-Sadi O,Ertel W,Lohan A

更新日期：2012-11-05 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...

journal_title：Cells

authors： Kalailingam P,Tan HB,Pan JY,Tan SH,Thanabalu T

更新日期：2019-02-02 00:00:00

abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...

journal_title：Cells

authors： Kim YS,Choi J,Yoon BE

更新日期：2020-09-27 00:00:00

abstract：:The Rho GTPases comprise a subfamily of the Ras superfamily of small GTPases. Their importance in regulation of cell morphology and cell migration is well characterized. According to the prevailing paradigm, Cdc42 regulates the formation of filopodia, Rac1 regulates the formation of lamellipodia, and RhoA triggers the...

journal_title：Cells

authors： Aspenström P

更新日期：2019-07-21 00:00:00

abstract：:The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aqu...

journal_title：Cells

authors： de Mello Santos T,Cavariani MM,Pereira DN,Schimming BC,Chuffa LGA,Domeniconi RF

更新日期：2019-09-17 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

journal_title：Cells

authors： Fields GB

更新日期：2019-08-27 00:00:00

abstract：:Specific nuclear sub-compartments that are regions of fundamental processes such as gene expression or DNA repair, contain phosphoinositides (PIPs). PIPs thus potentially represent signals for the localization of specific proteins into different nuclear functional domains. We performed limited proteolysis followed by ...

journal_title：Cells

authors： Sztacho M,Šalovská B,Červenka J,Balaban C,Hoboth P,Hozák P

更新日期：2021-01-04 00:00:00

abstract：:Parkinson's Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. Th...

journal_title：Cells

authors： Miraglia F,Colla E

更新日期：2019-03-07 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:The turnip Brassica rapa has important economic value and represents a good model system to study gene function in crop plants. ERF/AP2 transcription factors are a major group of proteins that are often involved in regulating stress-responses and developmental programs. Some ERF/AP2 proteins are targets of CULLIN3-bas...

journal_title：Cells

authors： Mooney S,Al-Saharin R,Choi CM,Tucker K,Beathard C,Hellmann HA

更新日期：2019-04-10 00:00:00

abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...

journal_title：Cells

authors： Osei ET,Booth S,Hackett TL

更新日期：2020-07-15 00:00:00

abstract：:Peripheral nerve injury (PNI) leads to the loss of motor, sensory, and autonomic functions, and often triggers neuropathic pain. During the last years, many efforts have focused on finding new therapies to increase axonal regeneration or to alleviate painful conditions. Still only a few of them have targeted both phen...

journal_title：Cells

authors： Romeo-Guitart D,Casas C

更新日期：2020-03-27 00:00:00

abstract：:To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA signature in HNSCC, both strands of the miR-99a-duplex (miR-99a-5p: the guide strand, and miR-99a-3p: the passen...

journal_title：Cells

authors： Okada R,Koshizuka K,Yamada Y,Moriya S,Kikkawa N,Kinoshita T,Hanazawa T,Seki N

更新日期：2019-11-28 00:00:00

abstract：:Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...

journal_title：Cells

authors： Mélik Parsadaniantz S,Réaux-le Goazigo A,Sapienza A,Habas C,Baudouin C

更新日期：2020-02-25 00:00:00

abstract：:The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...

journal_title：Cells

authors： Del Favero G,Mayer RM,Dellafiora L,Janker L,Niederstaetter L,Dall'Asta C,Gerner C,Marko D

更新日期：2020-03-31 00:00:00

abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...

journal_title：Cells

authors： Smialek MJ,Ilaslan E,Sajek MP,Swiercz A,Janecki DM,Kusz-Zamelczyk K,Wozniak T,Kotecki M,Handschuh L,Figlerowicz M,Jaruzelska J

更新日期：2020-04-16 00:00:00

abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...

journal_title：Cells

authors： Lindner R

更新日期：2017-02-10 00:00:00

abstract：:More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...

journal_title：Cells

authors： Kang JH,Lee SH,Lee JS,Oh SJ,Ha JS,Choi HJ,Kim SY

更新日期：2020-06-16 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...

journal_title：Cells

authors： Nally FK,De Santi C,McCoy CE

更新日期：2019-06-05 00:00:00

abstract：:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...

journal_title：Cells

authors： Huguet F,Flynn S,Vagnarelli P

更新日期：2019-07-07 00:00:00

abstract：:Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich (TTAGGG) tandem repeats which play an important role in maintaining genome stability, premature aging and onsets of many diseases. Majority of the telomere are replicated by conventional DNA replication, and only the last bit of the...

journal_title：Cells

authors： Amir M,Khan P,Queen A,Dohare R,Alajmi MF,Hussain A,Islam A,Ahmad F,Hassan I

更新日期：2020-02-04 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00

abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...

journal_title：Cells

authors： Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi C

更新日期：2019-12-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...

journal_title：Cells

authors： Hu M,Bogoyevitch MA,Jans DA

更新日期：2019-11-11 00:00:00

abstract：:It is well known that fibroblast growth factor receptor 2 (FGFR2) interacts with its ligand of fibroblast growth factor (FGF) therefore exerting biological functions on cell proliferation and differentiation. In this study, we first reported that the FGFR2 gene could generate a circular RNA of circFGFR2, which regulat...

journal_title：Cells

authors： Chen X,Ouyang H,Wang Z,Chen B,Nie Q

更新日期：2018-11-06 00:00:00