Abstract：
:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.
journal_name
Cellsjournal_title
Cellsauthors
Rinkenbaugh AL,Baldwin ASdoi
10.3390/cells5020016subject
Has Abstractpub_date
2016-04-06 00:00:00issue
2issn
2073-4409pii
cells5020016journal_volume
5pub_type
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