Molecular Regulations and Functions of the Transient Receptor Potential Channels of the Islets of Langerhans and Insulinoma Cells.

abstract：:Mitotic spindles are highly organized, microtubule (MT)-based, transient structures that serve the fundamental function of unerring chromosome segregation during cell division and thus of genomic stability during tissue morphogenesis and homeostasis. Hence, a multitude of MT-associated proteins (MAPs) regulates the dy...

journal_title：Cells

authors： Peta C,Tsirimonaki E,Samouil D,Georgiadou K,Mangoura D

更新日期：2020-10-23 00:00:00

abstract：:Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interes...

journal_title：Cells

authors： Dai Z

更新日期：2019-07-20 00:00:00

abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...

journal_title：Cells

authors： Song W,Wang F,Chen L,Ma R,Zuo X,Cao A,Xie S,Chen X,Jin X,Li H

更新日期：2019-09-05 00:00:00

abstract：:Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell typ...

journal_title：Cells

authors： Santos J,Hubert T,Milthorpe BK

更新日期：2020-03-04 00:00:00

abstract：:The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many replication dependent (RD) members. The protein has been shown to be indispensable for survival, and involved in multiple roles from DNA damage to chromosome segr...

journal_title：Cells

authors： Cheema MS,Good KV,Kim B,Soufari H,O'Sullivan C,Freeman ME,Stefanelli G,Casas CR,Zengeler KE,Kennedy AJ,Eirin Lopez JM,Howard PL,Zovkic IB,Shabanowitz J,Dryhurst DD,Hunt DF,Mackereth CD,Ausió J

更新日期：2020-05-08 00:00:00

abstract：:The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs) of m. diaphragma and m. EDL. Intracellular microelectrode recor...

journal_title：Cells

authors： Gaydukov A,Bogacheva P,Tarasova E,Molchanova A,Miteva A,Pravdivceva E,Balezina O

更新日期：2019-07-22 00:00:00

abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...

journal_title：Cells

authors： Chu J,Lu M,Pfeifer CG,Alt V,Docheva D

更新日期：2020-09-08 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell signaling, both in healthy and pathologic conditions. Being nano-size...

journal_title：Cells

authors： Ailuno G,Baldassari S,Lai F,Florio T,Caviglioli G

更新日期：2020-12-01 00:00:00

abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...

journal_title：Cells

authors： Harel S,Sanchez-Gonzalez V,Echavarria R,Mayaki D,Hussain SN

更新日期：2020-07-02 00:00:00

abstract：:Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...

journal_title：Cells

authors： Kalailingam P,Tan HB,Pan JY,Tan SH,Thanabalu T

更新日期：2019-02-02 00:00:00

abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...

journal_title：Cells

authors： Cappellano G,Raineri D,Rolla R,Giordano M,Puricelli C,Vilardo B,Manfredi M,Cantaluppi V,Sainaghi PP,Castello L,De Vita N,Scotti L,Vaschetto R,Dianzani U,Chiocchetti A

更新日期：2021-01-07 00:00:00

abstract：:Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48-72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the li...

journal_title：Cells

authors： Estrella JFGL,Immanuel J,Wiley V,Simmons D

更新日期：2020-10-15 00:00:00

abstract：:Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...

journal_title：Cells

authors： Hansen JN,Rassmann S,Jikeli JF,Wachten D

更新日期：2018-12-26 00:00:00

abstract：:Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed. It is also known to be linked with several aspects of tumor malignancy in some types of human tumors, including invasion, metastasis, and cancer stemness. However, there are few reports on the expression of dog PDPN (dPDPN) in ...

journal_title：Cells

authors： Shinada M,Kato D,Kamoto S,Yoshimoto S,Tsuboi M,Yoshitake R,Eto S,Ikeda N,Saeki K,Hashimoto Y,Takahashi Y,Chambers J,Uchida K,Kaneko MK,Fujita N,Nishimura R,Kato Y,Nakagawa T

更新日期：2020-05-05 00:00:00

abstract：:A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD. The mechanism underlying stress-induced HMGB1 release is not known, but stress-associated glucocort...

journal_title：Cells

authors： Hisaoka-Nakashima K,Azuma H,Ishikawa F,Nakamura Y,Wang D,Liu K,Wake H,Nishibori M,Nakata Y,Morioka N

更新日期：2020-04-25 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:In response to inflammatory stimuli, immune cells reconfigure their metabolism and bioenergetics to generate energy and substrates for cell survival and to launch immune effector functions. As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and ...

journal_title：Cells

authors： Meyers AK,Zhu X

更新日期：2020-07-30 00:00:00

abstract：:The mammalian target of rapamycin (mTOR), is a serine/threonine protein kinase and belongs to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family. mTOR interacts with other subunits to form two distinct complexes, mTORC1 and mTORC2. mTORC1 coordinates cell growth and metabolism in response to environ...

journal_title：Cells

authors： Wei X,Luo L,Chen J

更新日期：2019-09-12 00:00:00

abstract：:The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aqu...

journal_title：Cells

authors： de Mello Santos T,Cavariani MM,Pereira DN,Schimming BC,Chuffa LGA,Domeniconi RF

更新日期：2019-09-17 00:00:00

abstract：:Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell proliferation and anti-apoptotic genes in order to stimulate cel...

journal_title：Cells

authors： Miyajima C,Kawarada Y,Inoue Y,Suzuki C,Mitamura K,Morishita D,Ohoka N,Imamura T,Hayashi H

更新日期：2020-01-09 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:Autoimmune rheumatic diseases (ARDs), affecting ~1-1.5% of all humans, are associated with considerable life long morbidity and early mortality. Early studies in the 1990s showed numerical changes of the recently discovered γδ T cells in the peripheral blood and in affected tissues of patients with a variety of ARDs, ...

journal_title：Cells

authors： Bank I

更新日期：2020-02-18 00:00:00

abstract：:We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity were followed by immunocytochemistry and transmission electron microscopy. Transcriptional ac...

journal_title：Cells

authors： Kobolak J,Teglasi A,Bellak T,Janstova Z,Molnar K,Zana M,Bock I,Laszlo L,Dinnyes A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Regenerative therapies based on autologous mesenchymal stem cells (MSC) as well as stem cells in general are still facing an unmet need for non-invasive sampling, availability, and scalability. The only known adult source of autologous MSCs permanently available with no pain, discomfort, or infection risk is...

journal_title：Cells

authors： Li H,Masieri FF,Schneider M,Kottek T,Hahnel S,Yamauchi K,Obradović D,Seon JK,Yun SJ,Ferrer RA,Franz S,Simon JC,Lethaus B,Savković V

更新日期：2020-09-10 00:00:00

abstract：:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have histor...

journal_title：Cells

authors： Thornton SM,Samararatne VD,Skeate JG,Buser C,Lühen KP,Taylor JR,Da Silva DM,Kast WM

更新日期：2020-04-15 00:00:00

abstract：:Retinal neurons, particularly retinal ganglion cells (RGCs), are susceptible to the degenerative damage caused by different inherited conditions and environmental insults, leading to irreversible vision loss and, ultimately, blindness. Numerous strategies are being tested in different models of degeneration to restore...

journal_title：Cells

authors： Pereiro X,Miltner AM,La Torre A,Vecino E

更新日期：2020-07-22 00:00:00

abstract：:Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts mostly generated from precursor-mRNA by a non-canonical event called back-splicing. They are highly stable, evolutionarily conserved, and wid...

journal_title：Cells

authors： Zaiou M

更新日期：2020-03-09 00:00:00

abstract：:Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Du...

journal_title：Cells

authors： Lee JE,Cranna NJ,Chahal AS,Quinn LM

更新日期：2012-12-05 00:00:00

abstract：:MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and n...

journal_title：Cells

authors： Ala U

更新日期：2020-06-28 00:00:00