Abstract：
:MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and non-coding RNA molecules can be targeted by the same miRNAs and can indirectly regulate each other by competing for them. These RNAs, otherwise known as competing endogenous RNAs (ceRNAs), lead to an additional post-transcriptional regulatory layer, where non-coding RNAs can find new significance. The miRNA-mediated interplay among different types of RNA molecules has been observed in many different contexts. The analyses of ceRNA networks in cancer and other pathologies, as well as in other physiological conditions, provide new opportunities for interpreting omics data for the field of personalized medicine. The development of novel computational tools, providing putative predictions of ceRNA interactions, is a rapidly growing field of interest. In this review, I discuss and present the current knowledge of the ceRNA mechanism and its implications in a broad spectrum of different pathologies, such as cardiovascular or autoimmune diseases, cancers and neurodegenerative disorders.
journal_name
Cellsjournal_title
Cellsauthors
Ala Udoi
10.3390/cells9071574subject
Has Abstractpub_date
2020-06-28 00:00:00issue
7issn
2073-4409pii
cells9071574journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis and gene expression, have substantial effects on RTK signal tran...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7030022
更新日期：2018-03-15 00:00:00
abstract：:Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100178
更新日期：2018-10-22 00:00:00
abstract：:Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this home...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7120224
更新日期：2018-11-22 00:00:00
abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020379
更新日期：2020-02-06 00:00:00
abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells6010006
更新日期：2017-02-10 00:00:00
abstract：:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7030020
更新日期：2018-03-10 00:00:00
abstract：:Chronic inflammation and abnormalities in Toll-like receptor (TLR) signaling pathways are associated with major depressive disorder (MDD). Our previous work reported that impaired negative regulators for the TLR pathways are associated with MDD. This study aimed to assess the association between the severity of depres...
journal_title：Cells
pub_type： 临床试验,杂志文章
doi：10.3390/cells8070647
更新日期：2019-06-27 00:00:00
abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030721
更新日期：2020-03-14 00:00:00
abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080937
更新日期：2019-08-20 00:00:00
abstract：:EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112505
更新日期：2020-11-19 00:00:00
abstract：:Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060543
更新日期：2019-06-05 00:00:00
abstract：:Retinal neurons, particularly retinal ganglion cells (RGCs), are susceptible to the degenerative damage caused by different inherited conditions and environmental insults, leading to irreversible vision loss and, ultimately, blindness. Numerous strategies are being tested in different models of degeneration to restore...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081759
更新日期：2020-07-22 00:00:00
abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071616
更新日期：2020-07-04 00:00:00
abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071602
更新日期：2020-07-02 00:00:00
abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051204
更新日期：2020-05-12 00:00:00
abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111402
更新日期：2019-11-07 00:00:00
abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040953
更新日期：2020-04-13 00:00:00
abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061483
更新日期：2020-06-18 00:00:00
abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8030215
更新日期：2019-03-04 00:00:00
abstract：:L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091039
更新日期：2019-09-05 00:00:00
abstract：:Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080893
更新日期：2019-08-14 00:00:00
abstract：:Intestinal dysbiosis has recently become known as an important driver of gastrointestinal and liver disease. It remains poorly understood, however, how gastrointestinal microbes bypass the intestinal mucosa and enter systemic circulation to enact an inflammatory immune response. In the context of chronic liver disease...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8111324
更新日期：2019-10-27 00:00:00
abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050504
更新日期：2019-05-24 00:00:00
abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080768
更新日期：2019-07-24 00:00:00
abstract：:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010117
更新日期：2021-01-10 00:00:00
abstract：:Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010008
更新日期：2018-12-22 00:00:00
abstract：:Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110221
更新日期：2018-11-21 00:00:00
abstract：:Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. While originally reported to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in the m...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells3030914
更新日期：2014-09-12 00:00:00
abstract：:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102312
更新日期：2020-10-17 00:00:00
abstract：:Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreatic transdifferentiation (PT), due to t...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102227
更新日期：2020-10-02 00:00:00
