Newborn Screening Samples for Diabetes Research: An Underused Resource.

abstract：:Infectious endocarditis (IE) remains one of the deadliest heart diseases with a high death rate, generally following thrombo-embolic events. Today, therapy is based on surgery and antibiotic therapy. When thromboembolic complications in IE patients persist, this is often due to our lack of knowledge regarding the path...

journal_title：Cells

authors： Hannachi N,Lepidi H,Fontanini A,Takakura T,Bou-Khalil J,Gouriet F,Habib G,Raoult D,Camoin-Jau L,Baudoin JP

更新日期：2020-08-13 00:00:00

abstract：:While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signali...

journal_title：Cells

authors： Ziller N,Kotolloshi R,Esmaeili M,Liebisch M,Mrowka R,Baniahmad A,Liehr T,Wolf G,Loeffler I

更新日期：2020-10-03 00:00:00

abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...

journal_title：Cells

authors： Fischer I,Nickel AC,Qin N,Taban K,Pauck D,Steiger HJ,Kamp M,Muhammad S,Hänggi D,Fritsche E,Remke M,Kahlert UD

更新日期：2020-12-15 00:00:00

abstract：:The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system, which, via hormones and growth factors, can in turn regulate b...

journal_title：Cells

authors： Sirotkin AV

更新日期：2016-11-24 00:00:00

abstract：:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...

journal_title：Cells

authors： Cha YJ,Koo JS

更新日期：2020-07-27 00:00:00

abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...

journal_title：Cells

authors： Khan S,Ricciardelli C,Yool AJ

更新日期：2021-01-22 00:00:00

abstract：:We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity were followed by immunocytochemistry and transmission electron microscopy. Transcriptional ac...

journal_title：Cells

authors： Kobolak J,Teglasi A,Bellak T,Janstova Z,Molnar K,Zana M,Bock I,Laszlo L,Dinnyes A

更新日期：2020-05-01 00:00:00

abstract：:Wnt/β-catenin signaling plays vital role in the regulation of cellular proliferation, migration, stem cells cell renewal and genetic stability. This pathway is crucial during the early developmental process; however, the distinct role of Wnt/β-catenin signaling during pre-implantation period of bovine embryonic develo...

journal_title：Cells

authors： Sidrat T,Khan AA,Idrees M,Joo MD,Xu L,Lee KL,Kong IK

更新日期：2020-04-09 00:00:00

abstract：:The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation results in the P53-dependent activation of a subset of genes that is highly induced during brain development and neuronal maturation, a feature that these genes reportedly share with circular RNAs (circRNAs). Interestingly, some ...

journal_title：Cells

authors： Mfossa ACM,Thekkekara Puthenparampil H,Inalegwu A,Coolkens A,Baatout S,Benotmane MA,Huylebroeck D,Quintens R

更新日期：2019-07-26 00:00:00

abstract：:Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human BPIFB4 gene protects cardiac function in the ...

journal_title：Cells

authors： Faulkner A,Dang Z,Avolio E,Thomas AC,Batstone T,Lloyd GR,Weber RJ,Najdekr L,Jankevics A,Dunn WB,Spinetti G,Vecchione C,Puca AA,Madeddu P

更新日期：2020-05-21 00:00:00

abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...

journal_title：Cells

authors： Bonsignori M,Moody MA

更新日期：2012-03-21 00:00:00

abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...

journal_title：Cells

authors： Karvonen H,Barker H,Kaleva L,Niininen W,Ungureanu D

更新日期：2019-08-02 00:00:00

abstract：:Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreatic transdifferentiation (PT), due to t...

journal_title：Cells

authors： La QT,Ren B,Logan GJ,Cunningham SC,Khandekar N,Nassif NT,O'Brien BA,Alexander IE,Simpson AM

更新日期：2020-10-02 00:00:00

abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...

journal_title：Cells

authors： Sehadova H,Takasu Y,Zaloudikova A,Lin YH,Sauman I,Sezutsu H,Rouhova L,Kodrik D,Zurovec M

更新日期：2020-12-11 00:00:00

abstract：:The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening. Nowadays, three-dimensional (3D) cultures, including spheroids, are acknowledged to be a better model of the in viv...

journal_title：Cells

authors： Demuynck R,Efimova I,Lin A,Declercq H,Krysko DV

更新日期：2020-03-13 00:00:00

abstract：:Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune condition in which ce...

journal_title：Cells

authors： Mak A,Schwarz H

更新日期：2019-09-06 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases with an increasing prevalence due to rising rates of obesity, metabolic syndrome and type II diabetes. Untreated NAFLD may progress to steatohepatitis (NASH) and ultimately liver cirrhosis. NAFLD is characterized by lipid accumulatio...

journal_title：Cells

authors： Asimakopoulou A,Engel KM,Gassler N,Bracht T,Sitek B,Buhl EM,Kalampoka S,Pinoé-Schmidt M,van Helden J,Schiller J,Weiskirchen R

更新日期：2020-05-28 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:Various types of data, including genomic sequences, transcription factor (TF) knockout data, TF-DNA interaction and expression profiles, have been used to decipher TF regulatory mechanisms. However, most of the genes affected by knockout of a particular TF are not bound by that factor. Here, I showed that this interes...

journal_title：Cells

authors： Dai Z

更新日期：2019-07-20 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...

journal_title：Cells

authors： Kim JY,Barua S,Huang MY,Park J,Yenari MA,Lee JE

更新日期：2020-09-02 00:00:00

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Escherichia coli (E. coli) has long been a popular model organism for basic biological research. In this paper, weighted gene co-expression network analysis (WGCNA) algorithm was ap...

journal_title：Cells

authors： Liu W,Li L,Long X,You W,Zhong Y,Wang M,Tao H,Lin S,He H

更新日期：2018-03-08 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00

abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...

journal_title：Cells

authors： Chu J,Lu M,Pfeifer CG,Alt V,Docheva D

更新日期：2020-09-08 00:00:00

abstract：:More than 50% of human cancers harbor TP53 mutations and increased expression of Mouse double minute 2 homolog(MDM2), which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence of wild-type p53, with a mutation rate of less than 4%. MDM2 is master regulator o...

journal_title：Cells

authors： Kang JH,Lee SH,Lee JS,Oh SJ,Ha JS,Choi HJ,Kim SY

更新日期：2020-06-16 00:00:00

abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...

journal_title：Cells

authors： Zonta F,Borgo C,Quezada Meza CP,Masgras I,Rasola A,Salvi M,Pinna LA,Ruzzene M

更新日期：2021-01-18 00:00:00

abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...

journal_title：Cells

authors： Marchetti AL,Guo H

更新日期：2020-11-06 00:00:00

abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...

journal_title：Cells

authors： Fantini V,Bordoni M,Scocozza F,Conti M,Scarian E,Carelli S,Di Giulio AM,Marconi S,Pansarasa O,Auricchio F,Cereda C

更新日期：2019-08-05 00:00:00

abstract：:Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism...

journal_title：Cells

authors： Gundamaraju R,Vemuri R,Chong WC,Myers S,Norouzi S,Shastri MD,Eri R

更新日期：2018-10-15 00:00:00

abstract：:Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...

journal_title：Cells

authors： Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

更新日期：2020-12-03 00:00:00