Abstract：
:The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aquaporins (AQPs) are important regulators of angiogenesis and the epididymal microenvironment and are associated with male fertility. We investigated the effects of maternal protein restriction on epididymal angiogenesis and AQP expression in the early stages of postnatal epididymal development. Pregnant rats were divided into two experimental groups that received either a normoprotein (17% protein) or low-protein diet (6% protein) during gestation and lactation. At postnatal day (PND)7 and PND14, male offspring were euthanized, the epididymides were subjected to morphometric and microvascular density analyses and to VEGF-A, VEGF-r2, AQP1 and AQP9 expression analyses. The maternal low-protein diet decreased AQP9 and VEGFr-2 expression, decreased epididymal microvascularity and altered the morphometric features of the epididymal epithelium; no changes in AQP1 expression were observed at the beginning of postnatal epididymal development. Maternal protein restriction alters microvascularization and affects molecules involved in the epidydimal microenvironment, resulting in morphometric alterations related to a delay in the beginning of epididymis postnatal development.
journal_name
Cellsjournal_title
Cellsauthors
de Mello Santos T,Cavariani MM,Pereira DN,Schimming BC,Chuffa LGA,Domeniconi RFdoi
10.3390/cells8091094subject
Has Abstractpub_date
2019-09-17 00:00:00issue
9issn
2073-4409pii
cells8091094journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050414
更新日期：2019-05-04 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all synthesized as single-pass transmembrane proteins and bind polypeptide ligands, mainly growth factors. It has long been thought that...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020304
更新日期：2014-04-22 00:00:00
abstract：:Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020393
更新日期：2020-02-08 00:00:00
abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020122
更新日期：2019-02-03 00:00:00
abstract：:Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060601
更新日期：2019-06-17 00:00:00
abstract：:Increasing evidence suggests that metabolic alterations may be etiologically linked to neurodegenerative disorders such as Parkinson's disease (PD) and in particular empathizes the possibility of targeting mitochondrial dysfunctions to improve PD progression. Under different pathological conditions (i.e., cardiac and ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092037
更新日期：2020-09-06 00:00:00
abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091927
更新日期：2020-08-20 00:00:00
abstract：:EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112505
更新日期：2020-11-19 00:00:00
abstract：:: Brains that are affected by Alzheimer's disease (AD) are characterized by the overload of extracellular amyloid β (Aβ) peptides, but recent data from cellular and animal models propose that Aβ deposition is preceded by intraneuronal accumulation of the direct precursor of Aβ, C99. These studies indicate that C99 acc...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051204
更新日期：2020-05-12 00:00:00
abstract：:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010117
更新日期：2021-01-10 00:00:00
abstract：:High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091019
更新日期：2019-09-02 00:00:00
abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091040
更新日期：2019-09-06 00:00:00
abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells5020016
更新日期：2016-04-06 00:00:00
abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...
journal_title：Cells
pub_type： 杂志文章,多中心研究
doi：10.3390/cells8121554
更新日期：2019-12-01 00:00:00
abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10020215
更新日期：2021-01-22 00:00:00
abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122689
更新日期：2020-12-15 00:00:00
abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9091919
更新日期：2020-08-19 00:00:00
abstract：:In response to inflammatory stimuli, immune cells reconfigure their metabolism and bioenergetics to generate energy and substrates for cell survival and to launch immune effector functions. As a critical component of the innate immune system, the nucleotide-binding and oligomerization domain, leucine-rich repeat, and ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081808
更新日期：2020-07-30 00:00:00
abstract：:Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080909
更新日期：2019-08-16 00:00:00
abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112389
更新日期：2020-10-31 00:00:00
abstract：:White adipose tissue (WAT) lipolysis contributes to energy balance during fasting. Lipolysis can proceed by the sequential hydrolysis of triglycerides (TGs) by adipose triglyceride lipase (ATGL), then of diacylglycerols (DGs) by hormone-sensitive lipase (HSL). We showed that the combined genetic deficiency of ATGL and...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050395
更新日期：2019-04-29 00:00:00
abstract：:An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven effi...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9091962
更新日期：2020-08-25 00:00:00
abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010181
更新日期：2021-01-18 00:00:00
abstract：:Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020386
更新日期：2014-05-06 00:00:00
abstract：:P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. This leads to insufficient therapeutic targeting of tumor populations, representin...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8101286
更新日期：2019-10-21 00:00:00
abstract：:The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030587
更新日期：2020-03-02 00:00:00
abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060053
更新日期：2018-06-02 00:00:00
abstract：:The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1010015
更新日期：2012-03-21 00:00:00
abstract：:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmona...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081875
更新日期：2020-08-11 00:00:00
abstract：:Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been f...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112369
更新日期：2020-10-28 00:00:00
