Abstract:
:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.
journal_name
Cellsjournal_title
Cellsauthors
Chao CM,Chong L,Chu X,Shrestha A,Behnke J,Ehrhardt H,Zhang J,Chen C,Bellusci Sdoi
10.3390/cells9081875subject
Has Abstractpub_date
2020-08-11 00:00:00issue
8issn
2073-4409pii
cells9081875journal_volume
9pub_type
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