Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System.

Abstract:

:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

journal_name

Cells

journal_title

Cells

authors

Chao CM,Chong L,Chu X,Shrestha A,Behnke J,Ehrhardt H,Zhang J,Chen C,Bellusci S

doi

10.3390/cells9081875

subject

Has Abstract

pub_date

2020-08-11 00:00:00

issue

8

issn

2073-4409

pii

cells9081875

journal_volume

9

pub_type

杂志文章,评审

相关文献

Cells文献大全
  • Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring.

    abstract::Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9092028

    authors: Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

    更新日期:2020-09-03 00:00:00

  • Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders.

    abstract::Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9020358

    authors: Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

    更新日期:2020-02-04 00:00:00

  • Dissimilar Appearances Are Deceptive-Common microRNAs and Therapeutic Strategies in Liver Cancer and Melanoma.

    abstract::: In this review, we summarize the current knowledge on miRNAs as therapeutic targets in two cancer types that were frequently described to be driven by miRNAs-melanoma and hepatocellular carcinoma (HCC). By focusing on common microRNAs and associated pathways in these-at first sight-dissimilar cancer types, we aim at...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010114

    authors: Linck-Paulus L,Hellerbrand C,Bosserhoff AK,Dietrich P

    更新日期:2020-01-02 00:00:00

  • Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.

    abstract::Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9071602

    authors: Harel S,Sanchez-Gonzalez V,Echavarria R,Mayaki D,Hussain SN

    更新日期:2020-07-02 00:00:00

  • Neuron-Astrocyte Interactions in Parkinson's Disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9122623

    authors: Miyazaki I,Asanuma M

    更新日期:2020-12-07 00:00:00

  • Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivator...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9122540

    authors: Mittermeier C,Konopa A,Muehlich S

    更新日期:2020-11-25 00:00:00

  • EpCAM as Modulator of Tissue Plasticity.

    abstract::The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9092128

    authors: Fagotto F

    更新日期:2020-09-19 00:00:00

  • Melatonin's Antineoplastic Potential Against Glioblastoma.

    abstract::Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030599

    authors: Moretti E,Favero G,Rodella LF,Rezzani R

    更新日期:2020-03-03 00:00:00

  • Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma.

    abstract::Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030780

    authors: Pant K,Peixoto E,Richard S,Gradilone SA

    更新日期:2020-03-23 00:00:00

  • Differential Expression and Localization of Branchial AQP1 and AQP3 in Japanese Medaka (Oryzias latipes).

    abstract::Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8050422

    authors: Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

    更新日期:2019-05-08 00:00:00

  • A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.

    abstract::The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal other damage response factors is critical for maintaini...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9071678

    authors: Rahman S,Canny MD,Buschmann TA,Latham MP

    更新日期:2020-07-13 00:00:00

  • On the Host Side of the Hepatitis E Virus Life Cycle.

    abstract::Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9051294

    authors: Oechslin N,Moradpour D,Gouttenoire J

    更新日期:2020-05-22 00:00:00

  • Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice.

    abstract::Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8080875

    authors: Sandrini L,Ieraci A,Amadio P,Zarà M,Mitro N,Lee FS,Tremoli E,Barbieri SS

    更新日期:2019-08-11 00:00:00

  • Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia.

    abstract::Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9092003

    authors: Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

    更新日期:2020-08-31 00:00:00

  • At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.

    abstract::BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030574

    authors: Kögel D,Linder B,Brunschweiger A,Chines S,Behl C

    更新日期:2020-02-28 00:00:00

  • Heat Stress-Induced Multiple Multipolar Divisions of Human Cancer Cells.

    abstract::Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8080888

    authors: Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

    更新日期:2019-08-13 00:00:00

  • CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway.

    abstract::Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9071706

    authors: Cheng CL,Yang SC,Lai CY,Wang CK,Chang CF,Lin CY,Chen WJ,Lin PY,Wu HC,Ma N,Lu FL,Lu J

    更新日期:2020-07-16 00:00:00

  • Rab GTPases: Switching to Human Diseases.

    abstract::Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8080909

    authors: Guadagno NA,Progida C

    更新日期:2019-08-16 00:00:00

  • The Endothelium as a Driver of Liver Fibrosis and Regeneration.

    abstract::Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9040929

    authors: Lafoz E,Ruart M,Anton A,Oncins A,Hernández-Gea V

    更新日期:2020-04-10 00:00:00

  • Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations.

    abstract::The experimental determination of the relative biological effectiveness of thermal neutron factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained while using mixed beams that consist of both neutrons and photons of various energies. A common weighting factor has been used for bo...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9102144

    authors: Pedrosa-Rivera M,Praena J,Porras I,Sabariego MP,Köster U,Haertlein M,Forsyth VT,Ramírez JC,Jover C,Jimena D,Osorio JL,Álvarez P,Ruiz-Ruiz C,Ruiz-Magaña MJ

    更新日期:2020-09-23 00:00:00

  • Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells.

    abstract::Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migra...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9081914

    authors: Alarcón S,Toro MLÁ,Villarreal C,Melo R,Fernández R,Ayuso Sacido A,Uribe D,San Martín R,Quezada C

    更新日期:2020-08-18 00:00:00

  • Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells.

    abstract::Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9122563

    authors: Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

    更新日期:2020-11-30 00:00:00

  • Differential Effects of Extracellular Vesicles of Lineage-Specific Human Pluripotent Stem Cells on the Cellular Behaviors of Isogenic Cortical Spheroids.

    abstract::Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8090993

    authors: Marzano M,Bejoy J,Cheerathodi MR,Sun L,York SB,Zhao J,Kanekiyo T,Bu G,Meckes DG Jr,Li Y

    更新日期:2019-08-28 00:00:00

  • Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles.

    abstract::Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020312

    authors: Merckx G,Hosseinkhani B,Kuypers S,Deville S,Irobi J,Nelissen I,Michiels L,Lambrichts I,Bronckaers A

    更新日期:2020-01-28 00:00:00

  • Evolution of Regulated Transcription.

    abstract::The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9071675

    authors: Bylino OV,Ibragimov AN,Shidlovskii YV

    更新日期:2020-07-12 00:00:00

  • Leukocyte-Derived Extracellular Vesicles in Blood with and without EpCAM Enrichment.

    abstract::Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8080937

    authors: Nanou A,Zeune LL,Terstappen LWMM

    更新日期:2019-08-20 00:00:00

  • Novel Approaches for Identifying the Molecular Background of Schizophrenia.

    abstract::Recent advances in psychiatric genetics have led to the discovery of dozens of genomic loci associated with schizophrenia. However, a gap exists between the detection of genetic associations and understanding the underlying molecular mechanisms. This review describes the basic approaches used in the so-called post-GWA...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010246

    authors: Golov AK,Kondratyev NV,Kostyuk GP,Golimbet AVE

    更新日期:2020-01-18 00:00:00

  • Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries.

    abstract:BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9122558

    authors: Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

    更新日期:2020-11-29 00:00:00

  • NF-κB and tPA Signaling in Kidney and Other Diseases.

    abstract::The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating h...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9061348

    authors: White S,Lin L,Hu K

    更新日期:2020-05-29 00:00:00

  • Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells.

    abstract::Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear. Low levels of ROS and enhanced antioxidant defenses are shown to contribute to increasing radioresistance. However, the role of Nrf2-Keap1-Bach1 signaling in the radio...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells10010083

    authors: Kamble D,Mahajan M,Dhat R,Sitasawad S

    更新日期:2021-01-06 00:00:00